Transition-metal-switchable divergent synthesis of nitrile-containing pyrazolo[1,5-a]pyridines and indolizines  

作　　者：Chongjiu Lu Min Ye Min Li Zhijierong Zhang Yuxin He Lipeng Long Zhengwang Chen 

机构地区：[1]Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province,Gannan Normal University,Ganzhou 341000,China

出　　处：《Chinese Chemical Letters》2021年第12期3967-3971,共5页中国化学快报（英文版）

基　　金：financial support from the Natural Science Foundation of Jiangxi Provincial Education Department (Nos. GJJ201422, GJJ190754, GJJ190776);Science and Technology Project of Ganzhou City。

摘　　要：Palladium-catalyzed oxidative formal [4 + 1] annulation of pyridine-substituted acrylonitriles toward divergent fused N-heterocycles synthesis is reported. The heterodifunctionalization reaction with Cu(OAc);and urea as the nitrogen source accesses to nitrile-substituted pyrazolo[1,5-a]pyridines in moderate to good yields, while the homodifunctionalization reaction with FeBr;leads to synthesis of nitrilesubstituted indolizines in excellent yields.

关 键 词：Divergent synthesis PALLADIUM-CATALYZED Annulation reaction Pyrazolo[1 5-a]pyridines INDOLIZINES 

分 类 号：O626[理学—有机化学]