Ag_(2)CO_(3)-catalyzed efficient synthesis of internal or terminal propargylicamines and chalcones via A^(3)-coupling under solvent-free condition  

作　　者：Ningbo Li Shitang Xu Xueyan Wang Li Xu Jie Qiao Zhiwu Liang Xinhua Xu 

机构地区：[1]Basic Medical College,Shanxi Medical University,Taiyuan 030001,China [2]Key Laboratory of Cellular Physiology,Ministry of Education,Shanxi Medical University,Changsha 410082,China [3]College of Chemistry and Chemical Engineering,Hunan University,Taiyuan 030001,China

出　　处：《Chinese Chemical Letters》2021年第12期3993-3997,共5页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China (Nos. 21802093, 21536003);Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (No. 2019L0408);the Ph D Start-up Foundation of Shanxi Medical University (No. 03201501) for the financial support。

摘　　要：Several simple, fast and practical protocols have been developed to synthesize internal or terminal propargylamines and chalcones via A^(3)-coupling reaction of aldehydes, amines, and alkynes catalyzed by an easily available catalyst Ag_(2)CO_(3)under solvent-free condition. The reaction proceeded smoothly to deliver various products in good-to-excellent yields with good functional group tolerance. Gram-scale preparation, bioactive molecule synthesis and asymmetric substrates have been demonstrated. Furthermore,plausible mechanisms for the synthesis of different products have been proposed.

关 键 词：Ag-catalyzed A^(3)-coupling SOLVENT-FREE PROPARGYLAMINES CHALCONES 

分 类 号：O621.251[理学—有机化学]