西酞普兰联合小剂量多塞平治疗广泛性焦虑症伴共病性失眠的效果分析  

Analysis The Effect of Citalopram Combined with Low Dose Doxepine in Patients with Generalized Anxiety Disorder with Comorbid Insomnia

作　　者：孙翔宇 SUN Xiangyu(Yantai Psychological Rehabilitation Hospital,Yantai 265200,China)

机构地区：[1]山东省烟台市心理康复医院,烟台265200

出　　处：《世界睡眠医学杂志》2022年第1期33-35,共3页World Journal of Sleep Medicine

摘　　要：目的:分析广泛性焦虑症伴共病性失眠患者应用西酞普兰与小剂量多塞平联合治疗的效果。方法:选取2017年10月至2020年3月山东省烟台市心理康复医院收治的广泛性焦虑症伴共病性失眠患者66例作为研究对象,按照随机数字表法分为观察组和对照组,每组33例。对照组患者服用氢溴酸西酞普兰治疗,观察组患者给予西酞普兰与小剂量多塞平联合治疗,采用匹兹堡睡眠指数量表(Pittsburgh Sleep Quality Index,PSQI)、汉密尔顿焦虑量表(Hamilton Anxiely Scale,HAMA)比较2组患者干预前后的睡眠质量、焦虑状态改善情况,比较2组患者治疗有效率。结果:干预后,观察组总有效率显著高于对照组,2组比较差异有统计学意义(P<0.05);观察组患者HAMA评分及PSQI评分均显著低于对照组,2组比较差异有统计学意义(P<0.05);观察组与对照组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:广泛性焦虑症伴共病性失眠患者接受西酞普兰及小剂量多塞平联合治疗可改善焦虑症伴失眠患者的症状,疗效确切,安全性高,值得临床推广使用。Objective:To analyze the efficacy of citalopram combined with low dose doxepine in patients with generalized anxiety disorder and comorbid insomnia.Methods:A total of 66 cases with generalized anxiety disorder and comorbid insomnia in Yantai Mental Rehabilitation Hospital of Shandong Province from October 2017 to March 2020 were selected as the research objects,and were divided into observation group and control group according to the random number table method,with 33 patients in each group.Control group was treated with citalopram hydrobromide,and the observation group was treated with citalopram combined with low-dose doxepin.Pittsburgh Sleep Quality Index(PSQI)and Hamilton Anxiely Scale(HAMA)were used to compared the sleep quality and anxiety state improvement before and after intervention,and compared the treatment efficiency at the same time.Results:After intervention,the total effective rate of the observation group was significantly higher than that of the control group,and the difference between the two groups was statistically significant(P<0.05).HAMA and PSQI scores in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the 2 groups(P>0.05).Conclusion:Citalopram combined with low-dose doxepine can improve the symptoms of patients with generalized anxiety disorder and comorbiditic insomnia,with definite efficacy and high safety,which is worthy of clinical application.

关 键 词：西酞普兰 多塞平 焦虑症 失眠 焦虑 睡眠质量 用药安全性 

分 类 号：R749.72[医药卫生—神经病学与精神病学] R338.63[医药卫生—临床医学]