基于5-羟色胺治疗肠易激综合征的中西医研究进展  

Research Progress of Traditional Chinese and Western Medicine in the Treatment of Irritable Bowel Syndrome Based on 5-hydroxytryptamine

作　　者：吴澎泞 熊帅 蒋晓涵 张怡[2] 梁超[2] 陈敏[2] WU Pengning;XIONG Shuai;JIANG Xiaohan;ZHANG Yi;LIANG Chao;CHEN Min(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Affiliated Hospital/Clinical Medical College,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学,四川省成都市610075 [2]成都中医药大学附属医院/临床医学院,四川省成都市610075

出　　处：《中国全科医学》2022年第15期1800-1806,共7页Chinese General Practice

基　　金：国家自然科学基金资助项目(81774321);国家重点研发计划“中医药现代化研究”重点专项(2019YFC1709004);科研能力提升“百人计划”(20-B05)。

摘　　要：肠易激综合征(IBS)是一种非胃肠道结构损害和生化异常的胃肠功能紊乱性疾病,其致病机制尚不十分清楚,西医采用多种药物、心理疗法、调节饮食等方式进行治疗,但效果欠佳。近年中医药治疗IBS受到广泛关注,尤其是便秘型与腹泻型,众多研究中针对5-羟色胺(5-HT)信号通路的中医药研究居多,且多获良效,故本文总结中医药基于5-HT治疗IBS的主要机制及成果,为后续研究提供参考。Irritable bowel syndrome(IBS) is a gastrointestinal disorder with no structural damage and biochemical abnormality,and its pathogenic mechanism is still unclear.Variety of drugs,psychotherapy,diet regulation and other methods have been used by modern medicine to relieve symptoms,but the effect is not satisfactory.In recent years,TCM treatment of IBS has attracted widespread attention,especially for constipation type and diarrhea type.Among the many experiments,most of the traditional Chinese medicine experiments aimed at the 5-HT signaling pathway have achieved good results.Therefore,this paper summarizes the main mechanisms and results of traditional Chinese medicine based on 5-HT in the treatment of IBS,in order to provide a reference for subsequent research.

关 键 词：肠易激综合征 5-羟色胺 血清素 中西医结合 治疗 综述 

分 类 号：R574.62[医药卫生—消化系统]