恶性肿瘤肝转移假性肝硬化发生机制及诊疗的研究进展  

Research progress of mechanism and diagnosis of pseudocirrhosis of liver metastasis of malignant tumor

作　　者：刘智慧 王祥旭 白引苗 王筱雯 张红梅 LIU Zhihui;WANG Xiangxu;BAI Yinmiao;WANG Xiaowen;ZHANG Hongmei(Department of Oncology,Xijing Hospital of Air Force Military Medical University,Shaanxi Xi'an 710032,China)

机构地区：[1]空军军医大学西京医院肿瘤科,陕西西安710032

出　　处：《现代肿瘤医学》2022年第7期1312-1315,共4页Journal of Modern Oncology

基　　金：空军军医大学西京医院2019学科助推项目(编号:XJZT19ML21)。

摘　　要：随着对恶性肿瘤的深入研究,越来越多的肿瘤患者接受到更规范更多线的治疗。更多线的化疗及靶向治疗,使一部分恶性肿瘤肝转移患者的肝脏发生类似肝硬化的形态学及临床改变,称之为假性肝硬化。由于假性肝硬化罕见,对于它的认识多来自于个案报道。因此,本文通过综述国内外关于假性肝硬化的个案报道及相关研究,对其发生机制、影像学及临床表现和诊断治疗进行全面阐述,使临床医生对假性肝硬化有一个全面认识,为临床医生早期诊断、早期治疗提供理论依据,以期降低假性肝硬化的误诊率及死亡率。With the in-depth study of malignant tumors,more and more cancer patients receive more standardized and more lines of treatment.More lines of chemotherapy and targeted therapy cause morphological and clinical changes similar to cirrhosis in the liver of some patients with liver metastases from malignant tumors,which is called pseudocirrhosis.Because pseudocirrhosis is rare,its understanding is mostly from case reports.Therefore,by reviewing the case reports and related studies on pseudocirrhosis at home and abroad,this paper comprehensively elaborates its mechanism,imaging and histological findings and diagnosis and treatment,so that clinicians have a comprehensive understanding of pseudocirrhosis and provide a theoretical basis for clinicians'early diagnosis and early treatment,in order to reduce the misdiagnosis rate and mortality of pseudocirrhosis.

关 键 词：假性肝硬化 恶性肿瘤 肝转移 

分 类 号：R730.6[医药卫生—肿瘤]