绝经前后女性浸润性乳腺癌危险因素分析  

Risk factors for invasive breast cancer in premenopausal and postmenopausal women

作　　者：毛淑平[1] 武文杰[1] 王苏[1] 郭盼盼 胡绘杰 吕印冠 李韶山[1] MAO Shuping;WU Wenjie;WANG Su;GUO Panpan;HU Huijie;LYU Yinguan;LI Shaoshan(The Second Department of General Surgery,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;School of Nursing,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)

机构地区：[1]新乡医学院第三附属医院普外二科,河南新乡453003 [2]新乡医学院护理学院,河南新乡453003

出　　处：《新乡医学院学报》2022年第2期127-130,共4页Journal of Xinxiang Medical University

基　　金：河南省教育厅科学技术研究重点项目(编号:14A320074)。

摘　　要：目的探讨绝经前后女性发生浸润性乳腺癌的危险因素。方法选择2018年5月至2020年7月新乡医学院第三附属医院收治的浸润性乳腺癌患者130例和同期筛查出的浸润性乳腺癌患者15例为研究对象(病例组,n=145),根据确诊时患者是否绝经将患者分为绝经前病例组(n=51)和绝经后病例组(n=94);另选择于新乡医学院第三附属医院同期体检健康者145例为对照组,根据体检时受试者是否绝经将受试者分为绝经前对照组(n=51)和绝经后对照组(n=94)。通过查阅病历资料收集所有受试者的一般临床资料,包括:年龄、身高、体质量、学历、初潮年龄、初产年龄、流产史、乳腺癌家族史、良性肿瘤手术史、是否哺乳。采用单因素和多因素logistic回归分析绝经前后发生浸润性乳腺癌的危险因素。结果绝经前病例组与绝经前对照组受试者的初潮年龄、流产史比较差异有统计学意义(P<0.05);绝经前病例组与绝经前对照组受试者的学历、初产年龄、体质量指数、乳腺癌家族史、良性肿瘤手术史、是否哺乳比较差异无统计学意义(P>0.05)。绝经后病例组与绝经后对照组受试者的初潮年龄、体质量指数、流产史、乳腺癌家族史比较差异有统计学意义(P<0.05);绝经后病例组与绝经后对照组受试者的学历、初产年龄、良性肿瘤手术史、是否哺乳比较差异无统计学意义(P>0.05)。Logistic回归分析结果显示,初潮年龄≤12岁、流产史是绝经前女性发生浸润性乳腺癌的危险因素(P<0.05);初潮年龄≤12岁、体质量指数≥28 kg·m^(-2)、流产史是绝经后女性发生浸润性乳腺癌的危险因素(P<0.05)。结论初潮年龄≤12岁、流产史是绝经前女性发生浸润性乳腺癌的危险因素,初潮年龄≤12岁、体质量指数≥28 kg·m^(-2)、流产史是绝经后女性发生浸润性乳腺癌的危险因素。Objective To investigate the risk factors of invasive breast cancer in premenopausal and postmenopausal women.Methods A total of 130 patients with invasive breast cancer who were admitted to the Third Affiliated Hospital of Xinxiang Medical University from May 2018 to July 2020 and 15 patients with invasive breast cancer screened out during the same period were selected as observation objects(case group,n=145),and the patients were divided into premenopausal case group(n=51)and postmenopausal case group(n=94)according to whether they were menopausal at the time of diagnosis.Another 145 healthy subjects who underwent physical examination during the same period in the Third Affiliated Hospital of Xinxiang Medical University were selected as the control group,and the subjects were divided into the premenopausal control group(n=51)and postmenopausal control group(n=94)according to whether the subjects were menopausal at the time of physical examination.The general clinical data of all subjects were collected by reviewing medical records,including age,height,weight,education,age at menarche,age at first birth,history of miscarriage,family history of breast cancer,history of benign tumor surgery and whether breastfeeding.The risk factors of invasive breast cancer before and after menopause were analyzed by univariate and multivariate logistic regression.Results There was significant differences in the age of menarche and history of abortion of subjects between the premenopausal case group and the premenopausal control group(P<0.05);there was no significant difference in the education background,age at first birth,body mass index,history of miscarriage,family history of breast cancer,history of benign tumor surgery and whether breastfeeding of subjects between the premenopausal case group and the premenopausal control group(P>0.05).There was significant differences in the age at menarche,body mass index,history of miscarriage,family history of breast cancer of subjects between the postmenopausal case group and the postm

关 键 词：浸润性乳腺癌 筛查 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]