Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19  

作　　者：Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Liuqin Yu Wenjia Chen Wenshan Hong Jia Wang Yao Chen Kun Wu Wangheng Hou Yali Zhang Shengxiang Ge Yixin Chen Quan Yuan Qiyi Tang Tong Cheng Yi Guan Ningshao Xia 

机构地区：[1]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Institute of Diagnostics and Vaccine Development in Infectious Diseases,School of Life Sciences,School of Public Health,Xiamen University,Xiamen 361000,China [2]State Key Laboratory of Emerging Infectious Diseases,The University of Hong Kong,Hong Kong,China [3]Joint Institute of Virology(Shantou University and The University of Hong Kong),Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases,Shantou University,Shantou 515063,China [4]Department of Microbiology,Howard University College of Medicine,Washington,DC 20059,USA [5]Research Unit of Frontier Technology of Structural Vaccinology,Chinese Academy of Medical Sciences,Xiamen 361102,China

出　　处：《Protein & Cell》2022年第1期72-77,共6页蛋白质与细胞（英文版）

摘　　要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 200 million people,causing coronavirus disease 2019(COVID-19)worldwide.Lungs are the primary target organ of SARS-CoV-2 infection.The mild COVID-19 cases develop symptoms of fever,fatigue,muscle weakness,chest pain,headache and cough(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020),while severe COIVD-19 cases might have pneumonia,breathing difficulties,multiple organ failure and death(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020).Both the clinicians and researchers have largely focused on the acute phase of COVID-19,but the long-term health consequences of the COVID-19 patients after clinical recovery remain less investigated.Several clinical cohorts demonstrated that some patients discharged from hospital still experience symptoms including fatigue,muscle weakness,chest pain,cough and breathing difficulties(Carfi et al.,2020;Lim et al.,2020;Huang et al.,2021).Moreover,severely impaired pulmonary diffusion capacities and abnormal chest imaging manifestations were observed in some convalescent patients(Huang et al.,2021).Surprisingly,residual virus(An et al.,2020;Yao et al.,2020;Kim et al.,2021)were detected in some convalescent patients.

关 键 词：ACUTE IMPAIRED PATHOGENESIS 

分 类 号：R563.1[医药卫生—呼吸系统]