网络成瘾共病肥胖的神经生物学机制研究进展  

Review on the neurobiological mechanism of comorbidity of internet addiction with obesity

作　　者：武潇 丁增波[1] 刘晓雅 张娅[2] 李素霞[1] 朱维莉[1] WU Xiao;DING Zeng-bo;LIU Xiao-ya;ZHANG Ya;LI Su-xia;ZHU Wei-li(National Institute on Drug Dependence,Peking University,Beijing 100191,China;Binzhou Medical University,Yantai 264033,Shandong,China)

机构地区：[1]北京大学中国药物依赖性研究所,北京100191 [2]滨州医学院,山东烟台264033

出　　处：《中国药物依赖性杂志》2022年第1期1-6,14,共7页Chinese Journal of Drug Dependence

基　　金：山东省自然科学基金重大基础研究项目(ZR2019ZD27)。

摘　　要：网络成瘾和肥胖的发生率日益升高,已成为全球普遍性的问题,严重影响各年龄段人群的生理和心理健康,本文对两者之间的相关性、共病的原因以及可能的神经生物学机制进行综述。大量流行病学证据表明,网络成瘾与肥胖的发病呈显著正相关,其可能的原因包括低体力活动和久坐、低睡眠质量、高热量饮食和不吃早餐等不良生活习惯以及焦虑、抑郁等心理因素。此外,网络成瘾和肥胖两者之间的核心共同机制主要是多巴胺奖赏通路受损,具有奖赏低敏化、冲动性增加、情绪失调的共同神经环路和分子基础。网络成瘾和肥胖之间的相互影响应当引起人们的重视,并采取有针对性的个体化干预策略以起到有效预防和治疗的作用。With the increasing prevalence of comorbidity of internet addiction with obesity, it has become a global problem, leading to a serious negative effects on both the physical and psychological health of people of all ages worldwide. In this paper, we reviewed the correlation between internet addiction and obesity, their common causes and possible neurobiological mechanisms. A great deal of epidemiological evidence showed that internet addiction was dramatically correlated with obesity. The underlying framework may be that internet addiction and obesity can improve each other through many mediators such as their unhealthy life habits(low physical activity and sedentary, low sleep quality, high-energy diet and no breakfast) and unhealthy psychological states. The core common mechanism between internet addiction and obesity is the dysfunction of dopamine reward pathway, they has the common neural circuit and molecular basis of reward hyposensitivity, impulsivity increase and emotional disorder. The efforts should be strengthened to the interaction between internet addiction and obesity in order to provide prevention and target treatment of comorbidity of internet addiction with obesity.

关 键 词：网络成瘾 问题性网络使用 超重 肥胖 心理因素 精神障碍 

分 类 号：R749[医药卫生—神经病学与精神病学]