脑出血后神经细胞铁死亡的研究进展  

Recent advance in neuron ferroptosis after intracerebral hemorrhage

作　　者：陈越 伍国锋 任思颖 Chen Yue;Wu Guofeng;Ren Siying(Clinical Medical School of Guizhou Medical University,Guiyang 550003,China;Department of Emergency,Affiliated Hospital of Guizhou Medical University,Guiyang 550003,China)

机构地区：[1]贵州医科大学临床医学院,贵阳550003 [2]贵州医科大学附属医院急诊科,贵阳550003

出　　处：《中华神经医学杂志》2022年第1期87-91,共5页Chinese Journal of Neuromedicine

基　　金：贵州省科学技术基金(黔科合基础[2020]1Y316);贵州医科大学附属医院国家自然科学基金培育基金(gyfynsfc[2020]-11)。

摘　　要：脑出血是急性脑血管病死亡率最高的卒中亚型,占所有脑卒中的15%~20%。脑出血后继发性神经功能损伤的机制尚不明确,是否与脑出血后铁沉积导致的神经细胞铁死亡有关值得进一步研究。本文现围绕脑出血后神经细胞铁死亡的可能机制及抑制方法、铁死亡的生物学标志物等内容综述如下。Intracerebral hemorrhage(ICH)is an acute cerebrovascular disease with the highest mortality in subtype of stroke,accounting for 15%-20%of all strokes.There was no specific treatment for ICH currently.The mechanism of secondary neurological impairment after ICH remains unclear.Whether it is related to the process of ferroptosis caused by iron deposition is worth to further discuss.This paper reviews the related published articles about ferroptosis,which include mechanisms,inhibition methods and biomarker of ferroptosis.

关 键 词：脑出血 铁死亡 氧化损伤 

分 类 号：R743.34[医药卫生—神经病学与精神病学]