Cucurbit[6]uril functionalized gold nanoparticles and electrode for the detection of metformin drug  

作　　者：Yaqi Wang Ling Ding Hui Yu Feng Liang 

机构地区：[1]The State Key Laboratory of Refractories and Metallurgy,School of Chemistry and Chemical Engineering,Wuhan University of Science and Technology,Wuhan 430081,China [2]Department of Civil and Environmental Engineering,Temple University,Philadelphia,PA 19122,United States

出　　处：《Chinese Chemical Letters》2022年第1期283-287,共5页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21807083);the Program for Innovative Teams of Outstanding Young and Middleaged Researchers in the Higher Education Institutions of Hubei Province(No.T201702)。

摘　　要：Based on the host-guest molecular recognition capability of cucurbit[6]uril(CB[6])modified on the gold surface,sensitive spectrophotometric and electrochemical methods for the detection of metformin(MET)have been developed.The molecular recognition between cucurbit[7]uril(CB[7])or CB[6]and MET is initially demonstrated and the related recognition mechanism is further deliberated.First,CB[6]-modified gold nanoparticles(AuNPs/CB[6])were synthesized and then characterized by ultraviolet visible light spectrum(UV–vis)and transmission electron microscopy(TEM).The aggregation of Au NPs/CB[6]prompted by MET triggered changes of color and the absorption spectrum,that explored for the visual identification and spectrophotometric determination of MET.Under the optimized detection conditions,the UV–vis spectrometry had a good linear relationship in the range of 6–700μmol/L,and the detection limit was 2μmol/L.In addition,a single-layer CB[6]-modified gold electrode(GE-CB[6])detection system for MET was constructed.As the concentration of MET in the solution continues to increase,the charge transfer resistance(Rct)in the Nyquist diagram of the electrochemical impedance method(EIS)continues to increase.In the concentration range from 10 pmol/L to 20 nmol/L,the logarithm of the MET concentration has a good linear relationship with Rct,and the detection limit of this method is 1.35 pmol/L.Both methods have good concentration sensitivity to MET in different concentration ranges,providing a powerful tool for the detection of MET.

关 键 词：METFORMIN CUCURBITURILS Host-guest interactions Gold nanoparticles Gold electrode 

分 类 号：R927.1[医药卫生—药学] TB383.1[一般工业技术—材料科学与工程]