Mufolinin A,an unprecedented ring A-seco 10-ethyllimonoid from Munronia unifoliolata  

作　　者：Yunpeng Sun Letian Cui Qiurong Li Pengfei Tang Yongyi Li Wenjun Xu Jun Luo Lingyi Kong 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Chemical Letters》2022年第1期516-518,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.31470416);the 111 Project from Ministry of Education of China and the State Administration of Foreign Export Affairs of China(No.B18056).ll supported in part by SciGrid,Chinese Academy of Sciences。

摘　　要：Mufolinin A(1),a ring A-seco rearranged limonoid with an unprecedented ethyl at C-10 and novel 6/6/6/5 fused-ring skeleton,together with three new potential precursors(ring A-seco limonoids,2–4)were isolated from Munronia unifoliolata.Their structures and absolute configurations were confirmed by nuclear magnetic resonance(NMR),high resolution electrospray ionization mass spectroscopy(HRESIMS),X-ray crystallography,electronic circular dichroism(ECD)calculations and NMR calculations with DP4+analyses.The unprecedented ethyl group of 1 was hypothesized to be derived from methyl migration and ring reduction rearrangement of ring A-seco limonoid 4.Compounds 2 and 4 showed significant multidrug resistance(MDR)reversal activities in MCF-7/DOX cells with reversal fold(RF)values of 13.1 and 8.0,respectively.

关 键 词：MELIACEAE Munronia unifoliolata LIMONOIDS ANTI-INFLAMMATORY Anti-multidrug resistance 

分 类 号：TQ28[化学工程—有机化工]