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作 者:陈琳 茹琴 周梅 吴钰祥[1] 肖华桥 司远仁 李超英 CHEN Lin;RU Qin;ZHOU Mei;WU Yuxiang;XIAO Huaqiao;SI Yuanren;LI Chaoying(School of Physical Education,Jianghan University,Wuhan,430056,China;Wuhan Institutes of Biomedical Sciences,Jianghan University,Wuhan,430056,China;Wuhan Wanji Psychiatric Hospital,Wuhan,430050,China)
机构地区:[1]江汉大学体育学院,武汉430056 [2]江汉大学武汉生物医学研究院,武汉430056 [3]武汉市万济精神病医院,武汉430050
出 处:《中国药物依赖性杂志》2021年第6期435-442,共8页Chinese Journal of Drug Dependence
基 金:武汉市科技局应用基础前沿项目(2019020701011499);国家自然科学基金面上项目(81971775)。
摘 要:目的:观察"戒毒一号"中药复方治疗甲基苯丙胺成瘾者精神、睡眠、认知及渴求症状的初步疗效。方法:选取自愿戒毒的甲基苯丙胺成瘾者为研究对象,在常规精神科对症治疗的基础上,使用"戒毒一号"中药复方进行治疗,采用量表评估精神、睡眠、认知及渴求症状,并进行组间对照和前后自身对照研究。结果:(1)组间对照研究:与对照组相比,治疗组简明精神量表评分和匹兹堡睡眠量表评分均下降(P<0.01),具有统计学意义;认知评分呈现升高趋势,但未见统计学意义;可视渴求量表评分下降(P<0.01),具有统计学意义。(2)前后自身对照研究:与治疗前相比,治疗组在治疗后,简明精神量表评分和匹兹堡睡眠量表评分均下降(P<0.01),具有统计学意义;认知评分呈现升高趋势,但差异未见统计学意义;可视渴求量表评分下降(P<0.01),具有统计学意义。结论:使用"戒毒一号"中药复方治疗,可以有效改善甲基苯丙胺成瘾者的毒品渴求程度;同时可以显著改善睡眠质量;显著改善冲动暴躁、猜疑、被害妄想、焦虑抑郁等甲基苯丙胺成瘾衍生的精神症状;具有改善认知功能的趋势。Objective:To observe the primary efficacy of “Jiedu No.1” in treating the mental, sleep, cognitive and craving symptoms of methamphetamine addicts. Methods:Methamphetamine addicts who voluntarily quit drugs were the subjects of the experiment. On the basis of the conventional symptomatic treatment in the department of psychiatry, the patients were treated with “Jiedu No.1” and the symptoms of mental, sleep, cognition and craving were evaluated with the scale. The control study was conducted between the groups and self-control study. Results:(1)Control study between groups: compared with the control group, the scores of concise mental scale and Pittsburgh sleep scale in the treatment group were significantly decreased(P<0.01). Cognitive score showed an increasing trend, but no significant difference was found. The scores of visual craving scale were significantly decreased(P<0.01).(2)Self-control study: compared with treatment before, the scores of the simple mental scale and Pittsburgh sleep scale were significantly decreased(P<0.01) after treatment;the cognitive score showed an increasing trend, but no significant difference was found;and the scores of visual craving scale were significantly decreased(P<0.01) after treatment in the treatment group. Conclusion:“Jiedu No.1” can effectively reduce the degree of drug craving of methamphetamine addicts. It can also significantly improve sleep quality. It significantly improved impulsivity irritability, suspicion, delusion of victims, anxiety and depression and other methamphetamine addiction derived mental symptoms. It tends to improve cognitive function.
关 键 词:“戒毒一号” 甲基苯丙胺成瘾 精神症状 睡眠 认知 渴求度
分 类 号:R749[医药卫生—神经病学与精神病学]
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