Curcumin Synergizes with Cisplatin to Inhibit Colon Cancer through Targeting the MicroRNA-137-Glutaminase Axis  

作　　者：Wen-hui FAN Feng-chun WANG Zhi JIN Lin ZHU Jian-xin ZHANG 

机构地区：[1]Department of Traditional Chinese Medicine,the Second Hospital of Shandong University,Jinan 250014,China [2]Department of Vascular Surgery,the Second Hospital of Shandong University,Jinan 250014,China

出　　处：《Current Medical Science》2022年第1期108-117,共10页当代医学科学（英文）

摘　　要：Objective:Colorectal cancer(CRC)is one of the most lethal and prevalent malignancies world-wide.Currently,surgery,radiotherapy and chemotherapy are clinically applied as common approaches for CRC patients.Cisplatin is one of the most frequently used chemotherapy drugs for diverse cancers.Although chemotherapeutic strategies have improved the prognosis and survival of cancer patients,development of cisplatin resistance has led to cancer recurrence.Curcumin,isolated from turmeric,has been used as an effective anti-cancer agent.However,the molecular mechanisms for curcumin-mediated cisplatin sensitivity of CRC have not been elucidated.

关 键 词：glutamine metabolism microRNA-137 CURCUMIN cisplatin resistant glutamina 

分 类 号：R73[医药卫生—肿瘤]