Cytogenetic Characteristics of Childhood Acute Lymphoblastic Leukemia:A Study of 1541 Chinese Patients Newly Diagnosed between 2001 and 2014  

作　　者：Meng-meng YIN Rui-chi WU Jing GAO Shao-yan HU Xiao-ming LIU Xiao-fan ZHU Shu-hong SHEN Jing-yan TANG Jing CHEN Qun HU 

机构地区：[1]Department of Pediatric Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Hematology/Oncology,Shanghai Children’s Medical Center,Shanghai Jiaotong University School of Medicine,Shanghai 200000,China [3]Children’s Hospital of Soochow University,Suzhou 215000,China [4]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300000,China

出　　处：《Current Medical Science》2022年第1期201-209,共9页当代医学科学（英文）

基　　金：This study was supported by grants from the National Natural Science Foundation of China(No.81670136),VIVA-China Children's Cancer Foundation.

摘　　要：Objective:Cytogenetic abnormalities have been proven to be the most valuable parameter for risk stratification of childhood acute lymphoblastic leukemia(ALL).However,studies on the prevalence of cytogenetic abnormalities and their correlation to clinical features in Chinese pediatric patients are limited,especially large-scale studies.Methods:We collected the cytogenetics and clinical data of 1541 children newly diagnosed with ALL between 2001 and 2014 in four Chinese hospitals,and retrospectively analyzed their clinical features,prognosis and risk factors associated with pediatric ALL.

关 键 词：CYTOGENETICS CHARACTERISTICS CHILDHOOD CHINESE acute lymphoblastic leukemia. 

分 类 号：R73[医药卫生—肿瘤]