比较米安色林与米那普仑对抑郁症患者的效果  

Comparison of mianserin and milnacipran in the treatment of the depression

作　　者：林正华 LIN Zhenghua(The Fourth People's Hospital of Liaocheng City,Liaocheng 252000,China)

机构地区：[1]聊城市第四人民医院,聊城252000

出　　处：《国际精神病学杂志》2022年第1期61-63,共3页Journal Of International Psychiatry

摘　　要：目的 比较米安色林与米那普仑治疗抑郁症的临床疗效及安全性。方法 将我院2016年2月~2019年2月收治的96例抑郁症患者随机分为两组,每组48例。对照组患者给予米安色林治疗,观察组给予米那普仑治疗,连续治疗3个月。采用汉密尔顿抑郁量表(HAMD)、社会功能量表(SFRS)、匹兹堡睡眠质量评分(PSQI)、汉密尔顿焦虑量表(HAMA)评价患者抑郁情绪、社会功能、睡眠质量以及焦虑情绪,比较两组患者治疗的不良反应发生情况及疗效。结果 两组治疗有效率差异无统计学意义(P>0.05);两组患者治疗后HAMD、PSQI评分、HAMA评分均显著降低,SFRS评分显著升高(P<0.05),且治疗后两组之间上述评分比较无明显差异(P>0.05);两组胃肠道反应、头痛/头晕、肝功能障碍、食欲减退发生率无明显差异(P>0.05),观察组性功能障碍、尿不尽发生率显著高于对照组(P<0.05)。结论 米安色林与米那普仑均能有效改善抑郁症患者焦虑、抑郁情绪,提升睡眠质量与社会功能,但米那普仑可能引起性功能障碍、尿不尽等副作用。Objective To study the clinical efficacy and safety of mianserin and milnacipran in the treatment of depression. Methods Ninety-six patients with depression admitted to our hospital from February 2016 to February 2019 were selected and randomly divided into the two groups. Patients in the control(n=48)group were treated with mianserin,and patients in the observation group(n=48)were treated with milnacipran for 3 months. The Hamilton depression scale(HAMD),social function scale(SFRS),Pittsburgh sleep quality score(PSQI),and Hamilton anxiety scale(HAMA)were used to evaluate depression,social function,sleep quality,and anxiety. The incidence of adverse reactions and the efficacy of the two groups was evaluated before and after treatment. Results There was no significant difference in the total effective rate between the two groups(P>0.05). After treatment,the HAMD,PSQI score and HAMA score were significantly lower,and the SFRS score was significantly higher in both of two groups(P<0.05). There was no significant difference in the scores of scales mentioned above between the two groups after treatment(P>0.05). There was no significant difference in the incidence of gastrointestinal reactions,headache/dizziness,liver dysfunction and loss of appetite between the two groups(P>0.05). The incidence of dysfunction and urinary insufficiency in study group was significantly higher than that of the control group(P<0.05). Conclusion Both mianserin and milnacipran can effectively improve anxiety and depression in patients with depression,improve sleep quality and social function,but milnacipran may cause side effects such as sexual dysfunction and urinary incontinence.

关 键 词：米安色林 米那普仑 抑郁症 不良反应 

分 类 号：R749.053[医药卫生—神经病学与精神病学]