Incidence of endophthalmitis after phacoemulsification cataract surgery:a Meta-analysis  

作　　者：Si-Lu Shi Xiao-Ning Yu Yi-Lei Cui Si-Fan Zheng Xing-Chao Shentu 

机构地区：[1]Eye Center of the Second Affiliated Hospital of Zhejiang University,School of Medicine,Hangzhou 310009,Zhejiang Province,China [2]GKT School of Medical Education,King's College London,London SEI 1UL,England,UK

出　　处：《International Journal of Ophthalmology(English edition)》2022年第2期327-335,共9页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China (No.81800869,No.81970781,No.81800807);the Natural Science Foundation of Zhejiang Province (No.LD21H120001)。

摘　　要：AIM:To evaluate the overall endophthalmitis incidence and the effectiveness of potential prophylaxis measures following phacoemulsification cataract surgery(PCS).METHODS:The Pub Med and Web of Science databases were searched from inception to April 30^(th),2021.We included studies that reported on the incidence of endophthalmitis following PCS.The quality of the included studies was critically evaluated with the Newcastle-Ottawa quality assessment scale.The random effect or the fixed-effects model was used to evaluated the pooled incidence based on the heterogeneity.The publication bias was assessed by Egger’s linear regression and Begg’s rank correlation tests.RESULTS:A total of 39 studies containing 5 878 114 eyes were included and critically appraised in the Meta-analysis.For overall incidence of endophthalmitis after PCS,the Meta-analysis yielded a pooled estimate of 0.092%(95%CI:0.083%-0.101%).The incidence appeared to decrease with time(before 2000:0.097%,95%CI:0.060%-0.135%;2000 to 2010:0.089%,95%CI:0.076%-0.101%;after 2010:0.063%,95%CI:0.050%-0.077%).Compared with typical povidone-iodine solution(0.178%,95%CI:0.071%-0.285%) and antibiotics subconjunctival injections(0.047%,95%CI:0.001%-0.095%),the use of intracameral antibiotics significantly reduced the incidence of endophthalmitis after PCS(0.045%,95%CI:0.034%-0.055%,RR:7.942,95%CI:4.510-13.985).CONCLUSION:Due to the advancement of phacoemulsification technology and the widespread use of intracameral antibiotics,the incidence of endophthalmitis following PCS shows a decreasing trend over time.The use of intracameral antibiotics administration will significantly reduce the risk of endophthalmitis.

关 键 词：ENDOPHTHALMITIS phacoemulsification cataract surgery intracameral antibiotics antibiotics subconjunctival injections typical povidone-iodine solution META-ANALYSIS 

分 类 号：R779.6[医药卫生—眼科]