肺癌化疗并发肺部感染患者血清炎性因子水平检测的意义  

Significance of detection of serum inflammatory factors levels in lung cancer patients with pulmonary infection on chemotherapy

作　　者：薛刚 郭华[1] 白洁[1] XUE Gang;GUO Hua;BAI Jie(Department of Respiratory and Critical Care Medicine,Xi'an Central Hospital,Xi'an 710003,China)

机构地区：[1]西安市中心医院呼吸与危重症医学科,西安710003

出　　处：《中国肿瘤临床与康复》2022年第2期167-170,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨肺癌化疗并发肺部感染患者血清高迁移率族蛋白-B1(HMGB1)、超敏C-反应蛋白(CRP)和降钙素原(PCT)水平的检测及临床意义。方法选取2018年4月至2020年11月间西安市中心医院收治的120例肺癌化疗患者,将肺癌化疗合并肺部感染的60例患者纳入观察组,将未发生肺部感染的60例患者纳入对照组,比较两组患者的血清炎性因子[CRP、PCT和白细胞介素-6(IL-6)指标]、HMGB1浓度、血清肿瘤标志物癌胚抗原(CEA)浓度、血常规与肝功能指标[前白蛋白(PA)、血蛋白(ALB)、谷草转氨酶(AST)、肌酐(SCR)、尿素氮(BUN)]和免疫指标[成熟T淋巴细胞(CD3^(+))、诱导性T细胞(CD4^(+))、抑制性T细胞(CD8^(+))、CD4^(+)/CD8^(+)、自然杀伤细胞(NK细胞)]水平变化情况。结果观察组患者血清CRP、PCT和IL-6指标水平均低于对照组,差异均有统计学意义(均P<0.05)。观察组患者血清HMGB1和CEA浓度均高于对照组,差异均有统计学意义(均P<0.05)。观察组患者血常规、PA、ALB、AST和SCR均高于对照组,BUN低于对照组,差异均有统计学意义(均P<0.05)。观察组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)和NK细胞水平均低于对照组,CD8^(+)高于对照组,差异均有统计学意义(均P<0.05)。结论肺癌化疗合并肺部感染患者的血清炎性因子、HMGB1浓度、CEA浓度、血常规与肝功能指标均高于肺癌患者,细胞免疫功能相对较弱,具有临床检测应用价值,值得推广。Objective To study the significance of detection of serum high mobility group protein(HMGB1),high sensitivity C-reactive protein(CRP)and procalcitonin(PCT)levels in patients with lung cancer complicated with pulmonary infection undergoing chemotherapy.Methods A total of 120 lung canc-er patients receiving chemotherapy were selected at Xi'an Central Hospital from April 2018 to November 2020.According to whether the patients had pulmonary infection,60 patients with pulmonary infection were enrolled in an observation group and 60 patients without pulmonary infection were enrolled in a control group.Changes in the levels of inflammatory factors including CRP,PCT and interleukin-6(IL-6),HMGB1,carcinoembryonic antigen(CEA),blood routine test,liver function including prealbumin(PA),albumin(ALB),aspartate transaminase(AST),serum creatinine(SCr),blood urea nitrogen(BUN),and indexes of immune system including mature CD3^(+)T lymphocyte,inducible CD4^(+)T lymphocyte,inhib-itive CD8^(+)T lymphocyte,CD4^(+)/CD8^(+)and natural killer(NK)cells were compared between the two groups,.Results The levels of CRP,PCT and IL-6 were significantly lower in the observation group than those in the control group(all P<0.05).The levels of HMGB1 and CEA were significantly higher in the observation group than those in the control group(all P<0.05).The levels of blood routine test,PA,ALB,AST,SCr were significantly higher in the observation group than in the control group and BUN was significantly lower in the observation group than in the control group(all P<0.05).The levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and NK cells were significantly lower in the observation group than those in the control group,while CD8^(+)was significantly higher in the observation group than in the control group(all P<0.05).Conclusion The serum inflammatory factors,high mobility group protein-1 concentration,serum cancer marker CEA concentration,blood routine and liver function indexes are high and the cellular immune function is relatively weak in lung cancer patient

关 键 词：肺肿瘤 药物疗法 肺部感染 高迁移率族蛋白1 炎性因子 血常规 肝功能 

分 类 号：R734.2[医药卫生—肿瘤]