血清胃功能三项联合癌胚抗原和癌抗原72-4在胃癌早期筛查中的价值  

Value of gastric function panel of three serum items combined with CEA and CA72-4 for the early screening of gastric cancer

作　　者：陈志娟[1] 卢彩侠 李艳艳 姚春蓉[1] CHEN Zhi-juan;LU Cai-xia;LI Yan-yan;YAO Chun-rong(Department of Medical Gastroenterology,Hanzhong Central Hospital of Shaanxi Province,Hanzhong 723000,China)

机构地区：[1]陕西省汉中市中心医院消化内科,汉中723000

出　　处：《中国肿瘤临床与康复》2022年第2期218-221,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨血清胃功能三项(血清胃泌素、胃蛋白酶1和胃蛋白酶2)联合癌胚抗原(CEA)及癌抗原72-4(CA72-4)检测在胃癌早期筛查中的应用价值。方法选取2019年9月至2020年12月间汉中市中心医院收治的具有上消化道症状的600例患者作为研究对象,对其进行内镜检查及病理学诊断,并以病理学诊断结果为金标准,将患者分为早期胃癌组(165例)及良性病变组(435例),并选取同期行健康检查的300名健康志愿者作为对照组,三组患者均接受血清胃功能三项及CEA、CA72-4检查,将检查结果进行综合对比。结果早期胃癌组的PGⅠ水平(65.23±3.25)ng/ml,低于良性病变组及对照组的(72.23±3.46)ng/ml及(104.45±4.47)ng/ml,差异均有统计学意义(P<0.05)。早期胃癌组的PGⅡ水平及胃泌素G-17水平分别为(22.23±3.23)ng/ml及(20.21±5.23)mmol/L,高于良性病变组的(19.56±2.67)ng/ml及(8.56±2.28)mmol/L与对照组的(15.45±2.24)ng/ml及(10.56±3.32)mmol/L,差异均有统计学意义(P<0.05)。早期胃癌组的CEA及CA72-4水平分别为(164.23±15.23)μg/L及(65.02±10.10)U/ml,高于良性病变组的(12.78±2.25)μg/L及(8.09±2.34)U/ml及对照组的(4.56±1.20)μg/L及(3.23±1.10)U/ml,差异均有统计学意义(P<0.05)。结论血清胃功能三项联合CEA、CA72-4检测,对早期胃癌的诊断有着显著价值,可进一步提高疾病的早期诊断率,为疾病的早期治疗提供科学指导,以延长患者的生存周期。Objective To explore the application value of gastric function panel of three serum items(serum gastrin, pepsin 1 and pepsin 2) combined with carcinoembryonic antigen(CEA) and cancer antigen 72-4(CA72-4) for the early screening of gastric cancer. Methods A total of 600 patients with upper gastrointestinal symptoms were selected at Hanzhong Central Hospital of Shaanxi Province from September 2019 to December 2020. Endoscopic examination and pathological diagnosis were performed on these participants. The results of pathological diagnosis were considered as the gold standard. Patients were categorized into an early-stage gastric cancer group(165 patients) and a benign lesion group(435 patients), and another 300 healthy volunteers who underwent health examinations during the same period were selected and included in a control group. Detection of gastric function panel of three serum items and CEA and CA72-4 was performed on the three groups to make a comprehensive comparison. Results The pepsinogen Ⅰ(PG Ⅰ) level was lower in the early-stage gastric cancer group(65.23±3.25 ng/ml) than in the benign lesion group(72.23±3.46 ng/ml) and in the control group(104.45±4.47 ng/ml(all P<0.05). The levels of PG Ⅱ and gastrin-17 were 22.23±3.23 ng/ml and 20.21±5.23 mmol/L, respectively in the early-stage gastric cancer group which were significantly higher than in the benign lesion group(19.56±2.67 ng/ml and 8.56±2.28 mmol/L, respectively) and the control group(15.45±2.24 ng/ml and 10.56±3.32 mmol/L, respectively)(all P<0.05). The levels of CEA and CA72-4 were 164.23±15.23 μg/L and 65.02±10.10 U/ml, respectively in the early-stage gastric cancer group, which were significantly higher than the benign disease group(12.78±2.25 μg/L and 8.09±2.34 U/ml, respectively) and the control group(4.56±1.20 μg/L and 3.23±1.10 U/ml, respectively)(all P<0.05). Conclusion The three items of serum gastric function combined with CEA and CA72-4 have significant value in the diagnosis of early gastric cancer, which can furthe

关 键 词：血清胃功能三项 癌胚抗原 癌抗原72-4 胃癌筛查 

分 类 号：R735.2[医药卫生—肿瘤]