原发性肝癌患者术后生存质量及影响因素调查分析  

Analysis of quality of life and its influencing factors in patients with primary liver cancer after operation

作　　者：蔡锋[1] 朱运海[1] 赵杰[1] 叶赛 CAI Feng;ZHU Yun-hai;ZHAO Jie;YE Sai(Department of Gastroenterology,Hepatobiliary Surgery,Shangqiu First Peoples Hospital,Sluingqiu,Henan 476000,China)

机构地区：[1]商丘市第一人民医院胃肠肝胆外科,河南商丘476000

出　　处：《中国卫生工程学》2022年第1期37-39,共3页Chinese Journal of Public Health Engineering

基　　金：河南省医学科技攻关计划项目(LHGJ20200935);河南省医学科技攻关计划项目(LHGJ20200927)。

摘　　要：目的探讨原发性肝癌患者术后生存质量及影响因素调查分析。方法选取2018年5月至2019年2月本院收治的原发性肝癌患者148例。收集患者性别、年龄、受教育程度、是否接受围术期加速康复处理、肿瘤直径、肿瘤包膜浸润情况、肿瘤包膜形成情况、是否存在微血管浸润及是否存在门静脉癌栓情况。术后12个月内嘱患者来医院复查,使用肝胆肿瘤治疗功能评定(FACT-Hep)量表评估术后生存质量。结果本次调查研究纳入的148例原发性肝癌患者的生存质量总评分(159.05±8.32)分。不同性别、年龄、受教育程度,是否行围术期加速康复处理,是否合并微血管浸润、门静脉癌栓的原发性肝癌患者术后生存质量比较差异均有统计学意义(均P<0.01);不同肿瘤直径、肿瘤包膜浸润、肿瘤包膜形成的原发性肝癌患者术后生存质量比较差异均无统计学意义(均P>0.05)。多因素Cox比例风险模型回归分析显示,年龄、微血管浸润、门静脉癌栓是原发性肝癌患者术后生存质量的独立危险因素(均P<0.01),围术期加速康复处理是原发性肝癌患者术后生存质量的保护因素(P<0.01)。结论原发性肝癌患者术后生存质量偏低,应重点关注高龄以及存在微血管浸润、门静脉癌栓的患者,采取积极的围术期加速康复处理措施。Objective To investigate the status and influencing factors of postoperative quality of life in patients with primary liver cancer.Methods 148 patients with primary liver cancer treated in our hospital from May 2018 to February 2019 were selected.The patients’gender,age,education level,whether they received perioperative accelerated rehabilitation treatment,tumor diameter,tumor envelope infiltration,tumor envelope formation,microvascular infiltration and portal vein tumor thrombus were collected.The patients came to the hospital for reexamination within 12 months after operation,and the postoperative quality of life was evaluated by the fact hep scale.Results The total score of quality of life of 148 patients with primary liver cancer was(159.05±8.32).There were significant differences in postoperative quality of life among primary liver cancer patients with different gender,age,education level,whether perioperative accelerated rehabilitation treatment,whether combined with microvascular infiltration and portal vein tumor thrombus(P<0.01);There was no significant difference in postoperative quality of life among patients with primary liver cancer with different tumor diameter,tumor envelope infiltration and tumor envelope formation(P>0.05).Multivariate Cox proportional hazards regression analysis showed that age,microvascular infiltration and portal vein tumor thrombus were independent risk factors(P<0.01)for postoperative quality of life of patients with primary liver cancer,and perioperative accelerated rehabilitation was the protective factor for postoperative quality of life of patients with primary liver cancer(P<0.01).Conclusion The quality of life of patients with primary liver cancer is low.We should focus on the elderly,patients with microvascular infiltration and portal vein tumor thrombus,and actively give perioperative accelerated rehabilitation.

关 键 词：原发性肝癌 根治性切除术 生存质量 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]