Inducing immunogenic cell death in immuno-oncological therapies  

作　　者：Dongdong Ti Xin Yan Jianshu Wei Zhiqiang Wu Yao Wang Weidong Han 

机构地区：[1]Department of Bio-therapeutic,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《Chinese Journal of Cancer Research》2022年第1期1-10,共10页中国癌症研究（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 31971378, 81830002, 31870873 and 31991171)

摘　　要：Immunotherapy has revolutionized cancer treatment and substantially improved patient outcomes with respect to multiple types of tumors.However,most patients cannot benefit from such therapies,mainly due to the intrinsic low immunogenicity of cancer cells(CCs)that allows them to escape recognition by immune cells of the body.Immunogenic cell death(ICD),which is a form of regulated cell death,engages in a complex dialogue between dying CCs and immune cells in the tumor microenvironment(TME),ultimately evoking the damage-associated molecular pattern(DAMP)signals to activate tumor-specific immunity.The ICD inducers mediate the death of CCs and improve both antigenicity and adjuvanticity.At the same time,they reprogram TME with a“cold-warmhot”immune status,ultimately amplifying and sustaining dendritic cell-and T cell-dependent innate sensing as well as the antitumor immune responses.In this review,we discuss how to stimulate ICD based upon the biological properties of CCs that have evolved under diverse stress conditions.Additionally,we highlight how this dynamic interaction contributes to priming tumor immunogenicity,thereby boosting anticancer immune responses.We believe that a deep understanding of these ICD processes will provide a framework for evaluating its vital role in cancer immunotherapy.

关 键 词：Immunogenic cell death damage-associated molecular pattern tumor immunogenicity antitumor immune responses 

分 类 号：R730.51[医药卫生—肿瘤]