艾司奥美拉唑、莫沙必利联合铝碳酸镁治疗胃食管反流性咽喉炎的临床疗效  

Clinical efficacy of esomeprazole and mosapride combined with hydrotalcite in treatment of gastroesophageal reflux laryngitis

作　　者：王海翠 牛美娜 李美荣 朱双双 王晓伟 WANG Haicui;NIU Meina;LI Meirong;ZHU Shuangshuang;WANG Xiaowei(Department of Pharmacy,The Fourth People’s Hospital of Langfang City-Affiliated Hospital of Chengde Medical College,Langfang 065700,China)

机构地区：[1]河北省廊坊市第四人民医院-承德医学院附属医院内科,廊坊065700

出　　处：《中国临床药学杂志》2022年第1期41-46,共6页Chinese Journal of Clinical Pharmacy

基　　金：廊坊市科技局资助项目(编号2019013117)。

摘　　要：目的探讨艾司奥美拉唑、莫沙必利联合铝碳酸镁治疗胃食管反流性咽喉炎(GERL)的临床疗效。方法将112例GERL患者随机分为对照组和观察组,各56例。对照组在慢性咽喉炎治疗基础上予艾司奥美拉唑镁肠溶片(20 mg,po,bid)+枸橼酸莫沙必利分散片(5 mg,po,tid),疗程8周;观察组在对照组基础上前2周加用铝碳酸镁咀嚼片(1 g,po,tid)。比较2组治疗总有效率、反流症状指数(RSI)、反流体征评分(RFS)、食管近端pH<4时间百分率、食管远端pH<4时间百分率、Demeester评分、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、促胃液素(GAS)、胃动素(MTL)、内皮素-1(ET-1)、一氧化氮(NO)、SF-36健康量表评分及不良反应的差异。结果观察组治疗后总有效率高于对照组(96.43%vs 82.14%,P<0.05)。与治疗前比较,2组治疗后RSI、RFS、食管近端pH<4时间百分率、食管远端pH<4时间百分率、Demeester评分、血清PGⅠ、ET-1、NO水平均下降(P<0.05),血清GAS、MTL水平及躯体评分、心理评分、总体健康评分增高(P<0.05),且观察组以上指标改善程度大于对照组(P<0.05)。2组所发生的不良反应均为轻度不良反应,发生率组间差异无统计学意义(P>0.05)。结论艾司奥美拉唑、莫沙必利联合铝碳酸镁对GERL的治疗效果优于艾司奥美拉唑联合莫沙必利。AIM To investigate the clinical efficacy of esomeprazole,mosapride combined with hydrotalcite in the treatment of gastroesophageal reflux laryngitis(GERL).METHODS Totally 112 GERL patients were randomly divided into control group and observation group with 56 patients in each group.The control group was treated with esomeprazole magnesium enteric-coated tablets(20 mg,po,bid)and mosapride citrate dispersible tablets(5 mg,po,tid)for 8 weeks.The observation group was treated with hydrotalcite chewable tablets(1 g,po,tid)for 2 weeks on the basis of the control group.The differences of total effective rate,reflux symptom index(RSI),reflux finding score(RFS),proximal esophageal pH<4 time percentage,distal esophageal pH<4 time percentage,Demeester score,pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),gastrin(GAS),motilin(MTL),endothelin-1(ET-1),nitric oxide(NO),the MOS item short from health survey(SF-36)and the adverse reactions were compared between 2 groups.RESULTS The total effective rate of the observation group was higher than that of the control group(96.43%vs 82.14%,P<0.05).Compared with before treatment,the level of RSI score,RFS,proximal esophageal pH<4 time percentage,distal esophageal pH<4 time percentage,Demeester score and serum PGⅠ,ET-1,NO decreased after treatament(P<0.05),the level of serum GAS,MTL and the score of bodily,psychological and overall healthy evaluation increased after treatament(P<0.05),and the improvement degree of above indexes in the observation group was greater than that in the control group(P<0.05).The adverse reactions occurred in both groups were mild,and there was no significant difference in incidence between 2 groups(P>0.05).CONCLUSION The therapeutic effect of esomeprazole and mosapride combined with hydrotalcite on GERL is better than esomeprazole combined with mosapride.

关 键 词：胃食管反流性咽喉炎 艾司奥美拉唑 莫沙必利 铝碳酸镁 

分 类 号：R571[医药卫生—消化系统] R766.5[医药卫生—内科学]