Capillary electrophoresis methods for impurity profiling of drugs:A review of the past decade  

作　　者：Mansi Shah Nrupesh Patel Nagja Tripathi Vivek K.Vyas 

机构地区：[1]Department of Pharmaceutical Analysis,Institute of Pharmacy,Nirma University,Ahmedabad,382481,Gujarat,India [2]Department of Pharmacognosy,Institute of Pharmacy,Nirma University,Ahmedabad,382481,Gujarat,India [3]Department of Pharmaceutical Chemistry,Institute of Pharmacy,Nirma University,Ahmedabad,382481,Gujarat,India

出　　处：《Journal of Pharmaceutical Analysis》2022年第1期15-28,共14页药物分析学报（英文版）

基　　金：The authors would like to thank Institute of Pharmacy,Nirma University,Ahmedabad,India for providing the necessary facilities。

摘　　要：Capillary electrophoresis(CE)is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures,analysis of biomolecules,and characterization of biopharmaceuticals.Currently,CE is the method of choice for the analysis of foodstuffs and the determination of adulterants.This article discusses the general theory and instrumentation of CE as well as the classification of various CE techniques.It also presents an overview of research on the applications of different CE techniques in the impurity profiling of drugs in the past decade.The review briefly presents a comparison between CE and liquid chromatography methods and highlights the strengths of CE using drug compounds as examples.This review will help scientists,fellow researchers,and students to understand the applications of CE techniques in the impurity profiling of drugs.

关 键 词：Capillary electrophoresis IMPURITIES Impurity profiling DRUGS 

分 类 号：R917[医药卫生—药物分析学]