疏肝理气中药治疗三阴性乳腺癌疗效Meta分析  

A Meta-analysis of Soothing Liver and Regulating Qi Herbs on Efficacy of Triple-negative Breast Cancer

作　　者：车思阳[1] 殷东风[2] 高宏[2] 冷雪峰[2] CHE Siyang;YIN Dongfeng;GAO Hong;LENG Xuefeng(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2022年第2期188-192,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家中医药管理局重大疑难疾病中西医临床协作试点项目(2018-10)。

摘　　要：目的系统评价疏肝理气类中药治疗三阴性乳腺癌的疗效。方法计算机检索中国知网(CNKI)、万方、维普、PubMed、The Cochrane Library数据库,检索以疏肝理气中药为主要干预措施,治疗三阴性乳腺癌的随机对照试验,查找时间设定为各数据库建库至2020年12月31日。由两名工作人员分别根据纳入标准进行文献检索、筛选和数据的提取,最后评估所筛选研究的偏倚风险,统计学软件选用RevMan 5.4。结果共纳入11个对照试验(RCT),686例患者。Meta分析结果显示:治疗组在总有效率[RR=1.39,95%CI(1.20,1.62),P<0.0001]、减少骨髓抑制率[RR=0.78,95%CI(0.69,0.87),P<0.0001]、减少消化道不良反应[RR=0.87,95%CI(0.78,0.98),P=0.02]、调节T细胞亚群[MD=0.38,95%CI(0.28,0.49),P<0.00001]等方面较对照组存在优势,差异有统计学意义(P<0.05);治疗组在降低3年或5年复发转移率方面和对照组相比无明显变化,差异无统计学意义(P>0.05)。结论根据Meta分析所得结果显示,疏肝理气类中药较单纯化疗组,可提高三阴性乳腺癌治疗总有效率、减少化疗后不良反应、提高自身免疫力,但对降低3年或5年复发转移率方面作用不明显。由于所纳入研究的质量普遍较低、包含的病例数量较少,上述结论仍需更多高质量、大样本的研究来证明结果的可靠性。Objective To systematically evaluate the efficacy of soothing liver and regulating Qi herbs on triple-negative breast cancer.Methods Databases including CNKI,WanFang,VIP,PubMed and the Cochrane library were searched to collect RCTs of soothing liver and regulating Qi herbs on triple-negative breast cancer.The retrieval time was from the database establishment time to December 31,2020.Two researchers screened the literatures,extracted the data,assessed risk of bias of the included literatures,and analyzed the data with Revman 5.4 statistical software.Results A total of 11 RCTs and 686 patients were included.Meta-analysis showed that:improving treatment efficiency[RR=1.39,95%CI(1.20,1.62),P<0.0001],reducing myelosuppression rate[RR=0.78,95%CI(0.69,0.87),P<0.0001]and reducing gastrointestinal toxicity[RR=0.87,95%CI(0.78,0.98),P=0.02],regulating T cell subsets[MD=0.38,95%CI(0.28,0.49),P<0.00001].Compared with the control group,the difference was statistically significant(P<0.05).However,there was no statistical difference between two groups in reducing the recurrence and Metastasis rate of 3 or 5 years(P>0.05).Conclusion According to the results of Meta-analysis,soothing liver and regulating Qi herbs can improve treatment efficiency,reduce adverse reactions and improve T cell subsets,and no effect on the control of recurrence and metastasis rate.However,due to the low quality of the included studies and small sample size,the above conclusions are still required to be verified by more highquality randomized controlled trials.

关 键 词：疏肝理气 三阴乳腺癌 Meta分析 随机对照试验 

分 类 号：R737.9[医药卫生—肿瘤]