胆固醇代谢与肿瘤免疫  

Cholesterol Metabolism and Tumor Immunity

作　　者：罗娜 时荣臣[2] 代荣阳 缪洪明 LUO Na;SHI Rong-chen;DAI Rong-yang;MIAO Hong-ming(College of Basic Medical Sciences,Southwest Medical University,Luzhou 646000,China;Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Army Medical University(Third Military Medical University),Chongqing 400038,China)

机构地区：[1]西南医科大学基础医学院,泸州646000 [2]陆军军医大学(第三军医大学)基础医学院生物化学与分子生物学教研室,重庆400038

出　　处：《四川大学学报（医学版）》2022年第2期335-341,共7页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(No.82173134)资助。

摘　　要：胆固醇是生物体内重要的脂质分子,参与细胞的膜性结构形成、胆汁酸代谢以及类固醇激素合成等,对细胞的结构和功能具有重要的调控作用。近年来,大量研究表明胆固醇代谢在肿瘤发生发展过程中发生了重编程。除了直接影响肿瘤细胞的生物学行为,胆固醇代谢重编程还可以调控肿瘤微环境中免疫细胞的抗瘤活性。本文回顾了肿瘤微环境中髓源抑制性细胞、肿瘤相关巨噬细胞、树突状细胞以及T淋巴细胞等免疫细胞的胆固醇代谢重编程及其相互作用。肿瘤微环境中胆固醇代谢与肿瘤免疫的关系呈现复杂性、多样性。肿瘤微环境中胆固醇代谢重编程在调控免疫细胞活性方面的异同以及具体调控的机制仍是一个尚未完全解决的问题。靶向干预免疫细胞的胆固醇代谢途径,有望成为胆固醇代谢在肿瘤免疫治疗的新策略。Cholesterol,an important lipid molecule of organisms,is involved in the formation of cell membrane structure,bile acid metabolism and steroid hormone synthesis,playing an important role in the regulation of cell structure and functions.In recent years,a large number of studies have shown that cholesterol metabolism is reprogrammed during tumor formation and development.In addition to directly affecting the biological behavior of tumor cells,cholesterol metabolic reprogramming also regulates the antitumor activity of immune cells in the tumor microenvironment.We reviewed herein the cholesterol metabolism reprogramming of and interactions among immune cells including myeloidderived suppressor cells(MDSCs),tumor-associated macrophages(TAMs),dendritic cells(DCs),and T cells in the tumor microenvironment.However,the relationship between cholesterol metabolism and tumor immunity in tumor microenvironment is complex and diversified.The differences and similarities of cholesterol metabolism reprogramming in tumor microenvironment in regulating immune cell activity and the specific regulatory mechanism are still unresolved issues.Targeted intervention of the cholesterol metabolism pathway of immune cells is expected to become a new strategy of cholesterol metabolism in tumor immunotherapy.

关 键 词：胆固醇 代谢 肿瘤 免疫调控 肿瘤微环境 

分 类 号：R730.2[医药卫生—肿瘤]