Particulate matter 2.5 induced hyperpigmentation in reconstructed human epidermis model(MelaKutis®)  

作　　者：Xiaojing Yang Fen Peng Jingyi Huang Zhou Chen Jianzhong Zhang 

机构地区：[1]Department of Dermatology,Peking University People’s Hospital,Beijing 100044,China [2]Department of Dermatology,Beijing Chao-Yang hospital,Capital Medical University,Beijing 100027,China

出　　处：《Chinese Medical Journal》2022年第4期502-504,共3页中华医学杂志（英文版）

基　　金：This study was supported by the National Natural Science Foundation of China(No.2101000271)。

摘　　要：To the Editor:Epidemiological studies have confirmed that fine particulate matter(PM2.5)is related to skin hyperpigmentation,but experimental evidence is lacking.[1]Here,we used normal human epidermal keratinocytes(NHEKs),melanocytes(NHEMs),and reconstructed human epidermis models(MelaKutis®)to investigate the impact of PM2.5 on skin melanogenesis.MelaKutis®is a 3D skin model with a stratified structure,which is composed of human keratinocytes and melanocytes.Its structure and metabolic features are highly similar to those of the natural human skin.Moreover,external factors can stimulate the melanocytes located in the basal layer to produce melanin,resulting in hyperpigmentation.In our study,to simulate the effect of PM2.5 on human skin,we utilized PM2.5 collected in Beijing,China.Zhang et al[2]previously analyzed the components of PM2.5(collected in Beijing)and revealed that benzo[a]pyrene(BAP)was one of the most abundant and toxic components of PM2.5.Thus,we chose BAP as positive control.

关 键 词：China PARTICULATE utilized 

分 类 号：R739.5[医药卫生—肿瘤]