针刺治疗非痴呆型血管性认知障碍临床疗效Meta分析  

Meta Analysis of Clinical Efficacy of Acupuncture in the Treatment of Vascular Cognitive Impairment No Dementia

作　　者：王玉琳[1,2] 张琳[2] 李超然[2] 刘佳[1] 赵健[1] 范程欣 张亚珂 杨添淞[2,3] WANG Yulin;ZHANG Lin;LI Chaoran;LIU Jia;ZHAO Jian;FAN Chengxin;ZHANG Yake;YANG Tiansong(The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,Heilongjiang,China;Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001 [2]黑龙江中医药大学,黑龙江哈尔滨150040 [3]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《辽宁中医药大学学报》2022年第1期30-35,共6页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81704170);博士后研究人员落户黑龙江科研启动资助金项目(LBH-Q18116);黑龙江中医药大学研究生创新科研项目(2020yjscx046);黑龙江中医药大学校青年名中医培养项目;全国中医药创新骨干人才项目(LBH-Q18117);孙申田青年人才基金项目(2020SC-01)。

摘　　要：目的评价针刺治疗非痴呆型血管性认知障碍(VCIND)的临床有效性。方法通过检索中国知网(CNKI)、维普数据库(VIP)、万方数据库(WanFang)、中国生物医学文献数据库(CBM)、Pubmed、EMbase、Cochrane library,对纳入的关于针刺治疗VCIND临床随机对照试验进行质量评价,用Review Manager 5.3软件进行Meta分析。结果获得文献14篇,共有患者897例,针刺组455例,对照组442例。7篇文献的有效率合并比值比(OR)=3.57,95%置信区间(CI)(2.23,5.73);13篇文献的蒙特利尔认知量表(MOCA)评分合并均数差值(MD)=1.47,95%CI(0.99,1.94);9篇文献的简易精神状态检查量表(MMSE)评分合并MD=1.17,95%CI(0.48,1.87);4篇文献的日常生活活动能力量表(ADL)评分合并MD=3.73,95%CI(2.77,4.69);4篇文献的Barthel指数合并MD=5.35,95%CI(3.86,6.83)。针刺法疗效优于对照组(P<0.05)。结论针刺疗法较非针刺疗法在治疗非痴呆型血管性认知障碍方面疗效更佳,但由于部分结局指标纳入文献较少且文献质量有待于提高,仍需更多试验设计严谨的高质量临床研究来进一步验证。Objective To evaluate the clinical efficacy of acupuncture in the treatment of vascular cognitive impairment no dementia(VCIND). Methods CNKI,VIP,WanFang,CBM,PubMed,EMBASE and Cochrane library were searched to evaluate the quality of clinical randomized controlled trials(RCTs)on acupuncture treatment of VCIND,and Meta-analysis was performed with Review Manager 5.3 software.Results 14 literatures were obtained,including 897 patients,455 patients in the acupuncture group and 442 patients in the control group. The combined effective rate of 7 articles was OR=3.57,95%CI(2.23,5.73);the combined MOCA score of 13 articles was MD=1.47,95%CI(0.99,1.94);the combined MMSE score of 9 literatures was MD=1.17,95%CI(0.48,1.87);the combined ADL score of 4 articles was MD=3.73,95%CI(2.77,4.69);and the combined Barthel index of 4 articles was MD=5.35,95%CI(3.86,6.83).The curative effect of acupuncture on patients with VCIND was better than that of control group(P<0.05).Conclusion Acupuncture therapy is more effective than non acupuncture therapy in the treatment of vascular cognitive impairment no dementia. However,due to the lack of included literature on some outcome indicators and the quality of literature needs to be improved,this study still needs to be further verified by more high-quality clinical studies with rigorous design.

关 键 词：非痴呆型血管性认知障碍 针刺 随机对照试验 META分析 

分 类 号：R749.13[医药卫生—神经病学与精神病学]