补肾健脑针法联合草酸艾司西酞普兰治疗重性抑郁障碍疗效观察  

Observation on the Therapeutic Effect of Acupuncture for Nourishing Kidney and Strengthening Brain Combined with Escitalopram Oxalate in Treatment of Major Depressive Disorder

作　　者：宫莉莉 李冬冬 李雪玉 GONG Lili;LI Dongdong;LI Xueyu(General Hospital of Northern Theater Command,Shenyang 110016,Liaoning,China)

机构地区：[1]北部战区总医院,辽宁沈阳110016

出　　处：《辽宁中医药大学学报》2022年第1期93-96,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：军队后勤科研重点项目(BLB19J012)。

摘　　要：目的探讨补肾健脑针法联合草酸艾司西酞普兰治疗重性抑郁障碍(MDD)的效果及可能机制。方法选取2017年1月—2018年12月北部战区总医院精神心理科收治的MDD患者90例,随机分为观察组和对照组,各45例。两组均采用草酸艾司西酞普兰进行治疗,观察组在药物基础上联合补肾健脑针法进行治疗。补肾健脑针灸法:主穴取百会、神庭、大钟,配以风池、内关、神门、足三里和三阴交。两组患者均治疗8周。治疗前后用汉密尔顿抑郁量表(HAMD-24)评估抑郁的严重程度;酶联免疫吸附试验检测血浆脑源性神经营养因子(BDNF)、神经生长因子(NGF)、5-羟色胺(5-HT)、去甲肾上腺素(NE)和5-羟吲哚乙酸(5-HIAA)表达水平;健康调查简表(SF-36)评估患者的生活质量。比较两组治疗效果和不良反应。结果治疗8周后,观察组HAMD-24评分低于对照组(P<0.05)。观察组BDNF、NGF、5-HT和NE水平高于对照组,而5-HIAA水平低于对照组(P<0.05)。观察组生理功能、情感职能、精神健康、社会功能和生命活力评分高于对照组(P<0.05)。观察组疗效优于对照组(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论补肾健脑针法可以提高草酸艾司西酞普兰治疗MDD的疗效,并且提高患者的生活质量,改善血浆BDNF、NGF、5-HT、NE和5-HIAA水平。Objective To explore the effect and possible mechanism of acupuncture for invigorating the kidney and brain combined with escitalopram oxalate in the treatment of major depressive disorder(MDD). Methods Between January 2017 and December 2018,90 patients with MDD admitted to the department of psychiatry,general hospital of the Northern theater command,were randomly divided into observation group and control group,with 45 cases in each group. Both groups were treated with escitalopram oxalate,and the observation group was treated with acupuncture for strengthening the kidney and strengthening the brain based on drugs. Acupuncture and moxibustion for invigorating the kidney and brain:the main acupoints are Baihui(GV20),Shenting(GV24),and Dazhong(KI4),with Fengchi(GB20),Neiguan(PC6),Shenmen(HT7),Zusanli(ST36)and Sanyinjiao(SP6).Patients in both groups were treated for 8 weeks. Before and after treatment,use the Hamilton depression scale(HAMD-24)to assess the severity of depression;enzyme-linked immunosorbent assay to detect the expression levels of brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),serotonin(5-HT),norepinephrine(NE)and 5-hydroxyindole acetic acid(5-HIAA);the MOS item short from health survey(SF-36)assesses the patients’ quality of life. The treatment effects and adverse reactions of the two groups were compared. Results After 8 weeks of treatment,the HAMD-24 score of the observation group was lower than that of the control group(P<0.05). The levels of BDNF,NGF,5-HT and NE in the observation group were higher than those in the control group,while the 5-HIAA levels were lower than those in the control group(P<0.05). The physical function,emotional function,mental health,social function and vitality scores of the observation group were higher than those of the control group(P<0.05). The observation group was better than the control group(P<0.05). There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The method of invigor

关 键 词：补肾健脑 针灸 草酸艾司西酞普兰 重性抑郁障碍 生活质量 

分 类 号：R749.41[医药卫生—神经病学与精神病学]