Investigation of the effect of malaria and home-based oral chloroquine treatment on biochemical indices of P.falciparum malaria infection in children under 5 years in jos metropolis  

作　　者：Olomu Segun Afolabi Samuel Yusufu Gazuwa Garba Ibrahim Hassan Okolo Selina Nnuaku 

机构地区：[1]Department of Biochemistry,University of Jos,Plateau,Nigeria [2]Department of Biochemistry,Abubakar Tafawa Balewa University,Bauchi,Nigeria [3]Paediatrics Department,Jos University Teaching Hospital(JUTH),Jos,Nigeria

出　　处：《Infectious Diseases Research》2022年第1期29-33,共5页传染病研究（英文）

摘　　要：Background:In Nigeria,malaria is a leading cause of hospital admission and death.The country accounts for highest malaria cases and deaths globally.About 25% of all malaria cases and deaths in the world occurs in Nigeria.In 2010,malaria was reported to account for 60% of all outpatient visits and responsible for 30% of all hospital admission of children under the age of five years leaving in Nigeria.Objective:The goal of this research work was to investigate the possible role of the state of protein nutrition,kidney and liver functions of the under 5 years children with P.falciparum malaria;the assessment of these biochemical parameters as possible indicator of P.falciparum infection in the studied subjects and the effect of home-based oral chloroquine treatment in these children leaving in Jos metropolis.Method:Total of 93 children within the age range of 1 to 59 months and leaving in Jos North,Central Nigeria were recruited for this cross-sectional study.Malaria parasite identification was done using microscopic examination of Leishman-stained thick and thin blood films while the complete blood count was carried out using Beckman Coulter Analyzer.Results:The serum albumin concentration of(37.63±0.82 g/L)obtained in the malaria-free children was higher than concentration of(34.07±1.90 g/L)obtained in the chloroquine treated children with malaria,but not different from those obtained in the untreated uncomplicated malaria(37.35±1.19 g/L)and untreated severe malaria(37.43±1.02 g/L)groups.The Serum globulin concentration of 35.09±1.95 g/L,obtained in the untreated simple malaria group was higher than 30.18±1.30 g/L in the control group,34.57±2.59 g/L in the untreated severe malaria group and chloroquine treated malaria with 30.71±2.38 g/L,respectively.Conclusion:This study suggests that the biochemical parameters of serum creatinine,serum albumin,total protein,and globulin,serum alkaline phosphatase,serum alanine aminotransferase and serum aspartate aminotransferase are not sensitive indicators of P.falcipa

关 键 词：CHLOROQUINE P.falciparum CHILDREN MALARIA pathogenesis 

分 类 号：R53[医药卫生—内科学]