致病杆菌属细菌代谢物抑菌活性研究进展  

Advances in antimicrobial substances from genus Xenorhabdus

作　　者：韩云飞 他永全 王勇[1,2] 冯俊涛 王永红[1,2] HAN Yunfei;TA Yongquan;WANG Yong;FENG Juntao;WANG Yonghong(College of Plant Protection,Northwest A&F University,Yangling 712100,Shaanxi Province,China;Shaanxi Research Center of Biopesticide Engineering&Technology,Northwest A&F University,Yangling 712100,Shaanxi Province,China)

机构地区：[1]西北农林科技大学植物保护学院,陕西杨凌712100 [2]陕西省生物农药工程技术研究中心,陕西杨凌712100

出　　处：《农药学学报》2022年第2期217-231,共15页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金(32072474);国家重点研发计划(2017YFD0201203).

摘　　要：致病杆菌属(Xenorhabdus)细菌是一类存在于昆虫病原线虫肠道内的共生菌,能够产生多种具有不同生物活性的次级代谢产物,其中一些化合物具有开发成为新农药的潜力。本文综述了致病杆菌属细菌中可产生抑菌活性物质的代表性菌株,较为全面地总结了近几十年来在致病杆菌属细菌代谢物中发现的抑菌活性化合物;对致病杆菌属细菌产生的部分抑菌活性化合物的抑菌作用机理进行了讨论,认为影响蛋白质合成是某些化合物发挥抑菌作用的重要途径。基于抑菌活性化合物的生物合成途径及相关调控因子,总结了从致病杆菌属细菌代谢物中发掘新化合物和提高特定活性化合物产量的方法。针对现阶段致病杆菌属细菌及其次级代谢产物研究应用中存在的问题提出了相应的对策,并简要概述了未来致病杆菌属细菌的研究发展方向。本文可为如何合理有效利用致病杆菌属细菌活性代谢物提供参考,对于促进致病杆菌属细菌及其次级代谢产物的应用具有重要意义。Xenorhabdus is a kind of symbiotic bacteria living in the intestinal tract of entomopathogenic nematodes and produces a variety of secondary metabolites with different biological activities,some of which have the potential to develop new pesticides.Antimicrobial compounds found in the secondary metabolites from Xenorhabdus genus in recent decades and representative strains that produced antimicrobial secondary metabolites were summarized in this paper.The mechanisms of some antimicrobial compounds produced by Xenorhabdus were discussed and the inhibition of protein synthesis was an important way for some compounds against microorganisms.The methods of exploring new compounds and improving the yield of specific antimicrobial compounds from secondary metabolites of genus Xenorhabdus were summarized based on their biosynthesis pathway and related regulatory factors.The research prospects of Xenorhabdus were generalized and some countermeasures were put forward in this article in view of the current problems in the research and application of Xenorhabdus and its secondary metabolites.This paper provides a reference for the reasonable and effective application of antimicrobial secondary metabolites of Xenorhabdus,which is of great significance in promoting the utilization of Xenorhabdus and its secondary metabolites.

关 键 词：致病杆菌 昆虫病原线虫共生菌 代谢物 抑菌活性 Xenocoumacin 

分 类 号：S476.1[农业科学—农业昆虫与害虫防治] S482.292[农业科学—植物保护]