腮腺微小肿瘤的临床病理研究  

Clinicopathologic analysis of micro and mini parotid gland tumors

作　　者：李炳雨 唐祖南 胡耒豪 章文博[1] 于尧[1] 俞光岩[1] 彭歆[1] LI Bing-yu;TANG Zu-nan;HU Lei-hao;ZHANG Wen-bo;YU Yao;YU Guang-yan;PENG Xin(Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China)

机构地区：[1]北京大学口腔医学院·口腔医院口腔颌面外科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,口腔数字医学北京市重点实验室,北京100081

出　　处：《北京大学学报（医学版）》2022年第2期335-339,共5页Journal of Peking University:Health Sciences

摘　　要：目的:探讨直径≤20 mm的体积微小的腮腺肿瘤临床病理特点,为临床诊疗提供参考依据。方法:选择2012年12月至2020年4月于北京大学口腔医院口腔颌面外科手术治疗的腮腺肿瘤患者,收集术前CT检查肿瘤直径≤20 mm的患者相关临床资料,根据肿瘤直径大小分为直径11~20 mm组与直径≤10 mm组,对两组进行临床随访,比较一般情况、临床病理特点及预后。结果:共收集原发性上皮性腮腺肿瘤患者2067例,其中肿瘤直径≤20 mm者有685例(33.1%),男女性别比例为1∶1.93,平均年龄(45.3±13.8)岁(12~83岁),中位病程12个月(1周至30年)。685例中良性肿瘤635例(92.7%),恶性肿瘤50例(7.3%),良恶性比例为12.7∶1;最常见的良性肿瘤为多形性腺瘤,最常见的恶性肿瘤为黏液表皮样癌。肿瘤直径≤10 mm的患者有74例,占肿瘤直径≤20 mm患者的10.8%(74/685)。肿瘤直径11~20 mm组(n=611)和≤10 mm组(n=74)患者的一般情况及病理学分型比较提示,两组在性别、年龄、病程上差异均无统计学意义(P>0.05)。直径11~20 mm组患者良性肿瘤占92.8%(567/611),恶性肿瘤占7.2%(44/611),良恶性比例为12.9∶1;直径≤10 mm组良性肿瘤占91.9%(68/74),恶性肿瘤占8.1%(6/74),良恶性比例为11.3∶1,两者间差异无统计学意义(P>0.05)。对50例恶性肿瘤患者进行临床随访,中位随访时间为39.5个月(1~91个月),有2例患者局部复发,其中1例死亡,总体2年生存率为93.7%,5年生存率为89.3%。结论:直径≤20 mm的体积微小的腮腺肿瘤以良性多见,手术是主要治疗手段,其中的腮腺恶性肿瘤预后良好,应积极进行早期手术治疗。Objective:To investigate the clinicopathological characteristics of micro and mini parotid gland tumors and to provide reference for their clinical diagnosis and treatment.Methods:Patients with parotid gland tumors treated in the Department of Oral and Maxillofacial Surgery,Peking University School and Hospital of Stomatology from December 2012 to April 2020 were selected.Relevant clinical data of the patients with tumor diameter≤20 mm detected by preoperative CT were collected to analyze the clinicopathological characteristics and prognosis of micro and mini parotid gland tumors.And the collected data were divided into two groups with diameter 11-20 mm and diameter≤10 mm according to tumor diameter measured by preoperative CT.The clinicopathological differences between the two groups were statistically analyzed.Results:A total of 2067 patients with primary epithelial parotid gland tumors were collected,and 685 patients with tumor diameter≤20 mm were examined by CT,accounting for 33.1%.The ratio of male to female patients with micro and mini parotid gland tumors was 1∶1.93,the average age was(45.3±13.8)years(12-83 years),and the median course of disease was 12 months(1 week to 30 years).Among them,635 cases(92.7%)were benign tumors,50 cases(7.3%)were malignant tumors,and the ratio of benign to malignant was 12.7∶1.The most common benign tumor was pleomorphic adenoma,and the most common malignant tumor was mucoepidermoid carcinoma.The micro and mini parotid gland tumors were divided into 11-20 mm group(n=611)and≤10 mm group(n=74),the clinical characteristics comparison of the two groups of gender ratio,average age,course of di-sease had no statistical difference(P>0.05).In the 11-20 mm diameter group,the percentage of benign and malignant tumor was 92.8%(567/611)and 7.2%(44/611)respectively,and the ratio of benign to malignant tumors was 12.9∶1.In the≤10 mm diameter group,the percentage of benign and malignant tumor was 91.9%(68/74)and 8.1%(6/74)respectively,and the ratio of benign to malignant tu

关 键 词：腮腺肿瘤 肿瘤体积 病理学 临床 

分 类 号：R739.87[医药卫生—肿瘤]