溃疡性结肠炎患者的口臭研究  

Study on halitosis in patients with ulcerative colitis

作　　者：钱进 钱孝先 田尧 QIAN Jin;QIAN Xiaoxian;TIAN Yao(Department of Gastroenterology,Haian People’s Hospital,Haian 226600;Department of Gastroenterology,Minhang Hospital,Fudan University,China)

机构地区：[1]江苏省海安市人民医院消化内科,江苏海安226600 [2]复旦大学附属闵行医院消化内科

出　　处：《胃肠病学和肝病学杂志》2022年第3期316-318,322,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金青年科学基金项目(81900494)。

摘　　要：目的观察溃疡性结肠炎(ulcerative colitis,UC)住院患者治疗前后的口臭变化及其与疾病活动程度的关系。方法研究组纳入2018年1月至2020年12月收治的53例活动期UC住院患者,予以头孢他啶、奥硝唑、美沙拉嗪等药物治疗。对照组纳入同期收治的性别、年龄匹配的结肠息肉内镜下治疗的住院患者76例。评估两组患者入院当日的口臭评分及改良Mayo评分,并比较UC患者治疗7 d后口臭评分及改良Mayo评分改善情况。口臭评分采用感官分析法,按Rosenberg标准,以患者主诉结合口气闻诊为标准,由两位固定医师评定,按0~5级记分法记录。结果活动期UC患者入院当日口臭评分显著高于对照组[(3.34±1.04)分vs(2.00±1.06)分,P=0.000],治疗后口臭评分显著降低[(2.38±0.71)分vs(3.34±1.04)分,P=0.000],但仍显著高于对照组[(2.38±0.71)分vs(2.00±1.06)分,P=0.025],口臭评分与改良Mayo评分呈正相关(r=0.585,P=0.000)。结论UC患者易伴发口臭,控制肠道炎症、抗感染等治疗能减轻口臭,改善患者生活质量。Objective To observe the changes of halitosis and its relationship with disease activity in patients with ulcerative colitis(UC)before and after treatment.Methods The study group included 53 hospitalized patients with active UC from Jan.2018 to Dec.2020.They were treated with Ceftazidime,Ornidazole,Mesalazine and other medicines.The control group included 76 hospitalized patients matched for age and sex with colon polyps in the same period.The halitosis scoring and modified Mayo scoring of the two groups on the day of admission were evaluated,and the improvement of halitosis score and modified Mayo score of UC patients after 7 days of treatment were compared.The score of halitosis was evaluated by organoleptic test,according to Rosenberg’s standard,with the chief complaint of the patient combined with breath sniffing as the standard,assessed by 2 fixed doctors,and recorded according to the 0-5 grade scoring method.Results The halitosis score in the active UC group on the day of admission was significantly higher than that in the control group[(3.34±1.04)scores vs(2.00±1.06)scores,P=0.000].After treatment,the halitosis score was significantly decreased[(2.38±0.71)scores vs(3.34±1.04)scores,P=0.000],but still significantly higher than that in the control group[(2.38±0.71)scores vs(2.00±1.06)scores,P=0.025].Halitosis score was positively correlated with modified Mayo score(r=0.585,P=0.000).Conclusion UC patients are easy to develop halitosis.Controlling intestinal inflammation and anti infection therapy can reduce halitosis and improve their quality of life.

关 键 词：溃疡性结肠炎 口臭 美沙拉嗪 头孢他啶 奥硝唑 

分 类 号：R574.62[医药卫生—消化系统]