血清低氧诱导因子-1α和白细胞介素-6表达预测老年垂体瘤经鼻蝶手术治疗病人复发的临床意义  

Study on serum HIF-1 α and IL-6 expression in predicting the recurrence of elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery

作　　者：张丰铎 陈晓东[2] 吴泽玉[2] ZHANG Fengduo;CHEN Xiaodong;WU Zeyu(Department of Emergency,the 971 th Hospital of the Chinese People's Liberation Army Navy,Shandong,Qingdao 266071,China)

机构地区：[1]中国人民解放军海军第九七一医院急诊外科,青岛266071 [2]青岛大学附属医院神经外科

出　　处：《临床外科杂志》2022年第2期142-144,共3页Journal of Clinical Surgery

基　　金：山东省医药卫生科技发展计划项目(2018WS381)。

摘　　要：目的 观察血清低氧诱导因子(HIF)-1α、白细胞介素(IL)-6预测老年垂体瘤经鼻蝶手术治疗病人复发的价值。方法 2015年1月~2017年12月我院收治老年垂体瘤病人95例,采用经鼻蝶手术,并获得3年随访,观察病人复发情况。入院时检测血清HIF-1α、IL-6水平,分析二者预测治疗复发的临床意义。结果 95例病人中,复发18例,复发率为18.95%;复发组病人肿瘤侵袭性占比高于未复发组,入院时血清HIF-1α、IL-6水平高于未复发组,差异有统计学意义(P<0.05);绘制ROC曲线,结果显示,入院时血清HIF-1α、IL-6单独及联合预测垂体瘤手术病人复发风险的AUC均>0.80,有一定预测价值。结论 入院时血清HIF-1α、IL-6过表达可能与老年垂体瘤经鼻蝶手术治疗病人复发有关。Objective To observe the value of serum hypoxia inducible factor-1 α(HIF-1 α) and interleukin-6(IL-6) in predicting the recurrence of elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery.Methods 95 elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery treated in our hospital from January 2015 to December 2017 were selected, all patients received surgical treatment in our hospital and received the results of 3 months of follow-up, the recurrence of patients was observed;the serum HIF-1 α and IL-6 levels were detected at admission, the value of the two in predicting the recurrence of elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery was analyzed.Results Of 95 cases of elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery through follow-up evaluation, 18 cases had recurrence, the recurrence rate was 18.95%;the proportion of tumor invasion of patients in the recurrence group was higher than that in the non occurrence group, and the serum HIF-1 α and IL-6 levels were higher than those in the non occurrence group at admission(P<0.05);ROC curve was drawn, the results showed that the AUC of serum HIF-1 α and IL-6 alone or combined to predict the risk of recurrence in patients with pituitary adenoma surgery were all >0.80,which had certain predictive value.Conclusion The overexpression of HIF-1 α and IL-6 at admission may be associated with recurrence in elderly patients with pituitary adenomas after the treatment of transsphenoidal surgery, which had certain value in predicting the risk of recurrence in patients.

关 键 词：垂体瘤 经鼻蝶手术 低氧诱导因子-1Α 白细胞介素-6 复发 

分 类 号：R736.4[医药卫生—肿瘤]