生物可降解高分子交联剂的研究进展  

The Development of Biodegradable Polymer Crossing Linker

作　　者：李翠珍[1] 邓慧宇[1] 邹丽霞[1] LI Cui-zhen;DENG Hui-yu;ZOU Li-xia(School of Chemical Biology and Materials Science Institute,East China University of Technology,State Key Laboratory of Nuclear Resources and Environment,Nanchang 330013,China)

机构地区：[1]东华理工大学化学生物与材料科学学院,国家核资源与环境重点实验室,南昌330013

出　　处：《高分子通报》2022年第4期45-51,共7页Polymer Bulletin

基　　金：江西省聚合物微纳制造与器件重点实验室项目(1410600834);东华理工大学教改项目(DHJG-19-18)。

摘　　要：交联剂是制备水凝胶不可或缺的成分,其组成和结构影响了水凝胶的性能及应用。生物可降解性和生物相容性是作为组织工程支架、药物载体等生物医用材料所必需具备的性能。利用生物可降解性物质作为交联剂来制备化学凝胶,赋予了水凝胶上述性能,满足其作为生物医用材料的要求,拓宽水凝胶应用领域。本文主要总结了近年来多糖类(壳聚糖类、海藻酸类)、氨基酸类、酯类等天然和合成生物可降解高分子交联剂的合成及其在水凝胶制备中的应用,并展望了今后生物可降解交联剂的发展方向。Crossing linker was an indispensable component in the preparation of the hydrogel and its composition and structure influenced the properties and applications of hydrogels.Biodegradability and biocompatibility were essential properties of biomedical materials applied as drug carriers and tissue engineering scaffolds.The biodegradable agent as crossing linker could endow the hydrogel with biodegradability and biocompatibility and meet the requirements as biomedical materials.In this paper,the synthesis and application of natural and synthetic biodegradable polymer crossing linkers such as polysaccharide,polyester,poly(amino acid)were summarized.The development of the future biodegradable polymer crossing linker was also proposed.

关 键 词：生物可降解 高分子交联剂 水凝胶 

分 类 号：TQ427.26[化学工程]