血清GA和esRAGE与T2DM患者缺血性脑梗死发生风险的相关性  

The Association of Serum GA and eRAGE with the Risk of Ischemic Cerebral Infarction in Patients with T2DM

作　　者：王莎[1] 叶剑珍 韦鸿毓 刘建兵[1] WANG Sha;YE Jianzhen;WEI Hongyu;LIU Jianbing(Department of Endocrinology,Huangzhou People’s Hospital of Huanggang City,Huanggang 438000,China)

机构地区：[1]黄冈市黄州区人民医院内分泌科,湖北黄冈438000

出　　处：《标记免疫分析与临床》2022年第2期254-259,共6页Labeled Immunoassays and Clinical Medicine

基　　金：湖北省卫计委项目(编号:WJ2017M245)。

摘　　要：目的探究血清糖化白蛋白(GA)和晚期糖基化终末产物受体(esRAGE)是否能够预测2型糖尿病(T2DM)患者发生缺血性脑梗死风险的相关性研究。方法选取2018年8月至2020年10月在我院收治的79例糖尿病伴发脑梗死患者(DCI组)和82例单纯T2DM患者(T2DM组)为研究对象,另选择78例我院体检健康者作为对照组。比较3组血清GA和esRAGE水平。采用多因素Logistic回归模型分析血清GA和esRAGE水平与T2DM患者发生缺血性脑梗死风险的关系。采用受试者工作特征(ROC)曲线评估血清GA和esRAGE水平对T2DM患者发生缺血性脑梗死风险的诊断价值。使用SPSS Pearson法分析DCI组患者血清GA、esRAGE水平与血清hsCRP水平的关系。结果与对照组相比,DCI组和T2DM组患者血清GA水平升高,同时血清esRAGE水平降低,且DCI组血清GA水平亦高于T2DM组,血清esRAGE水平亦低于T2DM组,差异有统计学意义(P<0.05)。经多因素Logistic回归分析,血清GA>23.66%和esRAGE>0.32ng/mL是T2DM患者发生DCI的独立影响因素(P<0.05)。血清GA和esRAGE水平判断T2DM患者发生DCI的ROC曲线下面积分别为0.593(95%CI:0.505~0.681)、0.690(95%CI:0.610~0.771),对应截断值25.533%、0.221ng/mL,特异性86.6%、51.9%,灵敏度32.9%、79.3%。经Pearson法分析,DCI组患者血清GA、esRAGE水平与hsCRP相关(r=0.508,-0.333,P<0.05)。结论T2DM患者血清GA水平升高以及esRAGE水平降低与DCI发生风险有关,提示GA和esRAGE有望成为临床诊断和防治T2DM患者发生缺血性脑梗死风险的重要生物学分子。Objective To investigate whether serum glycolated albumin(GA)and advanced glycolated end product receptor(ESRAGE)predict the risk of ischemic cerebral infarction in patients with type 2 diabetes mellitus(T2DM).Methods A total of 79 patients with diabetes associated with cerebral infarction(DCI group)and 82 patients with T2DM alone(T2DM group)admitted to our hospital from August,2018 to October,2020 were selected as the research subjects,while 78 healthy subjects were selected as the control group.Serum GA concentration and esRAGE level were compared among the three groups.Multivariate logistic regression model was developed to investigate the relationship between serum GA and eRAGE levels and the risk of ischemic cerebral infarction in T2DM patients.Receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of serum GA and eRAGE levels in the risk of ischemic cerebral infarction in T2DM patients.SPSS Pearson method was applied to analyze the relationship between serum GA and eRAGE levels and serum hsCRP level in the DCI group.Results Compared with the control group,the serum GA level was increased in the DCI group and T2DM group,while the serum eRAGE level was decreased.Also,the level of serum GA in the DCI group was higher than that in the T2DM group,and the level of serum esRAGE was lower than that in the T2DM group(P<0.05).Multivariate logistic regression analysis showed that serum GA concentration>23.66%and eRAGE>0.32ng/mL were independent influencing factors of DCI in T2DM patients(P<0.05).The areas under the ROC curve for determining DCI in T2DM patients with serum GA and eRAGE levels were 0.593(95%CI:0.505-0.681)and 0.690(95%CI:0.690),respectively.0.610-0.771),with corresponding cut-off values of 25.533%,0.221 ng/mL,specificity of 86.6%,51.9%,sensitivity of 32.9%,79.3%,respectively.Pearson analysis showed that serum GA and eRAGE levels in DCI group were correlated with hsCRP(r=0.508,-0.333,P<0.05).Conclusion The increase of serum GA level and decrease of eRAGE level in T2DM pati

关 键 词：2型糖尿病 脑梗死 糖化白蛋白 ESRAGE 

分 类 号：R743.33[医药卫生—神经病学与精神病学]