Lipid-lowering effect of Oroxylum indicum(L.)Kurz extract in hyperlipidemic mice  

作　　者：Tanaporn Hengpratom Sajeera Kupittayanant Seekaow Churproong Griangsak Eumkeb 

机构地区：[1]Division of Health and Applied Sciences,Faculty of Science,Prince of Songkla University,Thailand [2]School of Preclinical Sciences,Institute of Science,Suranaree University of Technology,Nakhon Ratchasima,Thailand [3]Department of Family Medicine and Community Medicine,Institute of Medicine,Suranaree University of Technology,Nakhon Ratchasima,Thailand

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2022年第4期148-155,共8页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To investigate the effect of Oroxylum indicum fruit extract on high-fat diet-induced hyperlipidemic mice.Methods:The phytochemical composition of Oroxylum indicum fruit extract was determined by liquid chromatographymass spectrometry/mass spectrometry(LC-MS/MS)and gas chromatography-mass spectrometry.Forty-two male mice were used.The mice were divided into six groups:normal control,high-fat diet control,simvastatin treatment(20 mg/kg BW/day),and Oroxylum indicum fruit extract(100,200,300 mg/kg BW/day)treatment groups.Food intake,body weight,serum parameters,lipid profile,and histopathological lesions of the kidney,liver,and epididymal fat were observed.Results:LC-MS/MS results revealed four major components of Oroxylum indicum fruit extract:luteolin,apigenin,baicalein,and oroxylin A.Twenty-seven volatile oils were identified from Oroxylum indicum fruit extract.Daily oral administration of Oroxylum indicum fruit extract at 100 to 300 mg/kg BW/day significantly reduced the body weight,total cholesterol,triglyceride,and low-density lipoprotein cholesterol level(P<0.05),whereas high-density lipoprotein cholesterol was higher than the high-fat diet control group.Treatment with 300 mg/kg BW/day Oroxylum indicum fruit extract reduced the pathological lesion and prevented fat accumulation in the kidney and liver.Conclusions:Oroxylum indicum fruit extract has hypolipidemic effect in hyperlipidemic mice,and the active ingredients of Oroxylum indicum fruit extract,both flavonoids and volatile oils,should be further explored as an antihyperlipidemic agent.

关 键 词：Oroxylum indicum HYPERLIPIDEMIA Lipid-lowering effect EXTRACT MICE Anti-adipogenesis ANTIHYPERLIPIDEMIC Flavonoids Volatile oils 

分 类 号：R285.5[医药卫生—中药学]