睫状体无色素上皮腺瘤的超声影像特征  

Ultrasonographic features of adenoma of the nonpigmented ciliary epithelium

作　　者：李栋军 杨文利 魏文斌 顼晓琳 王子杨 陈伟 赵琦 李逸丰 崔蕊 沈琳 刘倩 魏串串 Li Dongjun;Yang Wenli;Wei Wenbin;Xu Xiaolin;Wang Ziyang;Chen Wei;Zhao Qi;Li Yifeng;Cui Rui;Shen Lin;Liu Qian;Wei Chuanchuan(Beijing Tongren Eye Center,Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment,Beijing Ophtahlmology&Visual Sciences Key Laboratory,Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科研究所,眼内肿瘤诊治研究北京市重点实验室,北京市眼科学与视觉科学重点实验室,医学人工智能研究与验证工信部重点实验室,北京100730

出　　处：《中华眼底病杂志》2022年第3期191-196,共6页Chinese Journal of Ocular Fundus Diseases

基　　金：首都卫生发展科研专项(首发2020-1-2052);北京市科委科技计划项目(Z201100005520045、Z181100001818003)。

摘　　要：目的:观察睫状体无色素上皮腺瘤(ANPCE)的超声影像特征。方法:回顾性病例对照研究。2014年1月至2021年10月于首都医科大学附属北京同仁医院眼科中心检查确诊的ANPCE患者31例31只眼(ANPCE组)以及同期检查确诊的睫状体黑色素瘤患者17例17只眼(对照组)纳入研究。两组患者年龄(t=-0.564)、性别构成比(χ^(2)=0.182)比较,差异均无统计学意义(P=0.576、0.670)。采用超声生物显微镜测量肿瘤高度、最大基底径、最大径、最大径与基底径比值及最大径与高度比值。观察肿瘤位置、形态、内回声强度、回声均匀性、声衰减程度、是否侵犯虹膜、继发虹膜膨隆、晶状体不全脱位等。两组患眼测量参数及观察指标比较采用独立样本t检验或χ^(2)检验。绘制受试者工作特征(ROC)曲线,确定ROC曲线下面积(AUC),筛选有鉴别诊断价值的参数指标。结果:ANPCE组、对照组患眼肿瘤最大径、高度、最大基底径、最大径与最大基底径比值、最大径与高度比值分别为(5.64±0.98)mm、(4.24±0.59)mm、(3.66±0.71)mm、1.58±0.34、1.34±0.19和(7.82±2.03)mm、(4.47±2.44)mm、(7.02±1.96)mm、1.13±0.16、2.09±1.06.ANPCE组肿瘤最大径、最大基底径、最大径与高度比值均小于对照组,最大径与最大基底径比值大于对照组,差异均有统计学意义(t=-4.159、-6.808、-2.924、6.257,P<0.05)。ANPCE组肿瘤主要表现为球形(87.1%,27/31)、声衰减不显著(77.4%,24/31)、较少侵犯根部虹膜(77.4%,24/31)、瘤体多位于睫状体冠部(74.2%,23/31);对照组肿瘤主要表现为半球形(47.1%,8/17)或球形(47.1%,8/17)、声衰减显著(76.5%,13/17)、多侵犯虹膜(70.6%,12/17)、瘤体多位于睫状体平坦部至冠部(76.5%,13/17)。两组患眼间肿瘤基底部位置、形态、声衰减程度、是否侵犯虹膜比较,差异均有统计学意义(χ^(2)=15.132、19.767、13.118、10.581,P<0.05)。ROC曲线分析结果显示,最大径与最大基底径比值,声�Objective To analyze the ultrasonographic features of adenoma of the nonpigmented ciliary epithelium(ANPCE).Methods A retrospective series of case studies.From January 2014 to October 2021,31 patients(31 eyes)with ANPCE(ANPCE group)were diagnosed in the eye center of Beijing Tongren Eye Center of Beijing Tongren Hospital,Capital Medical University,and 17 patients(17 eyes)with ciliary body melanoma(control group)diagnosed at the same time were selected as the control group.There was no significant difference in age(t=-0.564)and sex composition ratio(χ^(2)=0.182)between the two groups(P=0.576,0.670).All patients underwent ultrasound biomicroscopy to obtain the measurement parameters:tumor height,maximum basal diameter,maximum diameter,ratio of maximum diameter to basal diameter and ratio of maximum diameter to height;tumor location,shape,internal echogenicity intensity,echogenicity uniformity,degree of sound attenuation,invasion of iris,anterior displacement of the iris,lens subluxation were observed.The measurement parameters and observation indexes of the two groups were compared by independent sample t-test andχ^(2) test.Receiver operating characteristic(ROC)curve was drawn,area under the ROC curve(AUC)was determined,and parameter indicators with differential diagnosis value were screened.Results The maximum diameter,height,maximum basal diameter,ratio of the maximum diameter to the maximum basal diameter,and the ratio of the maximum diameter to the height of the tumors in the ANPCE group and the control group were 5.64±0.98 mm,4.24±0.59 mm,3.66±0.71 mm,1.58±0.34,1.34±0.19 and 7.82±2.03 mm,4.47±2.44 mm,7.02±1.96 mm,1.13±0.16,2.09±1.06.The maximum diameter,the maximum basal diameter,and the ratio of the maximum diameter to the height of the tumor in the ANPCE group were all smaller than those of the control group,and the ratio of the maximum diameter to the maximum basal diameter was greater than that of the control group,and the differences were statistically significant(t=-4.159,-6.808,-2.924,6.257;

关 键 词：腺瘤 睫状体 眼色素上皮 黑色素瘤 超声生物显微镜 

分 类 号：R739.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]