消化系统神经内分泌瘤临床病理观察  

Clinicopathological study of neuroendocrine tumor of digestive system

作　　者：仇加高 顾学文[2] 王翠梅[2] QIU Jiagao;GU Xuewen;WANG Cuimei(Department of Pathology,Gaoyou People’s Hospital,Jiangsu 225600;Department of Pathology,Subei People’s Hospital)

机构地区：[1]高邮市人民医院病理科,江苏225600 [2]江苏省苏北人民医院病理科

出　　处：《交通医学》2022年第1期37-40,共4页Medical Journal of Communications

摘　　要：目的:探讨消化系统神经内分泌瘤(neroendocrine tumor,NET)的临床病理学特征。方法:消化系统神经内分泌瘤患者162例,对其病理标本进行病理学检查和免疫组化染色,分析临床病理学特征与预后的关系。结果:162例消化系统NET中食管1例(0.62%),胃32例(19.75%),肠道101例(62.35%),胰腺23例(14.20%),阑尾3例(1.85%),肝脏1例(0.62%),胆管1例(0.62%)。肿块直径<2 cm 128例(79.0%),≥2 cm 34例(21.0%)。病理分级NET G1129例(79.6%),G219例(11.7%),G314例(8.7%)。无淋巴结转移151例(93.2%),有淋巴结转移11例(6.8%)。临床分期Ⅰ期136例(84.0%),Ⅱ期11例(6.8%),Ⅲ期8例(4.9%),Ⅳ期7例(4.3%)。免疫组化Syn阳性率100.0%,CD56阳性率80.7%,CgA阳性率72.2%。患者生存时间与肿块大小、病理分级、临床分期及淋巴结转移有关,均有统计学意义(P<0.05)。结论:消化系统神经内分泌瘤肿块直径<2 cm、无淋巴结转移、病理分级低、临床分期早的患者生存时间较长。Objective:To study the clinicopathological features of neroendocrine tumor(NET)in the digestive system.Methods:The clinical features,pathological morphology,stage,lymph node metastasis,immunohistochemistry and prognosis of 162 cases of neuroendocrine tumor of the digestive system(NET)were analyzed.Results:Among 162 cases,there were 90 males and 72 females,male:female=1.25:1;Age 9-83 years old,median age was 57 years old,there were 41 cases of age≤50 years,105 cases of age between 50 and 70 years old,16 cases of age>70 years old;1 case of esophagus,32 cases of stomach,101 cases of intestinal tract,23 cases of pancreas,3 cases of appendix,and 1 case of liver,1 case of bile duct;There were 128 cases with tumor diameter<2 cm and 34 cases with tumor diameter≥2 cm.There were 129 cases of NET G1,19 cases of NET G2 and 14 cases of NET G3,respectively.Pathological staging(pTNM)Ⅰ,Ⅱ,Ⅲ,Ⅳaccounted for 84.0%(136/162),6.8%(11/162),4.9%(8/162),and 4.3%(7/162),respectively;11 cases of lymph node metastasis;The positive rates of Syn,CD56 and CgA were 100%(162/162),80.7%(131/162)and 72.2%(117/162)by immunohistochemistry.Follow-up period ranged from 1 to 66 months and 10 patients died.The survival time of the digestive system neuroendocrine tumor was significantly correlated with tumor size,tumor grade,pathological stage and lymph node metastasis(P<0.05);tumor size was positively correlated with lymph node metastasis,NET grade and pathological stage(P<0.05).Conclusion:Neuroendocrine tumor of the digestive system is rare.Correct understanding of this kind of tumor is of great significance for clinical treatment and prognosis of patients.

关 键 词：消化系统 神经内分泌瘤 临床病理 免疫组化 

分 类 号：R735[医药卫生—肿瘤]