不同浓度艾芬地尔在社会应激模型中的抗抑郁作用  

Antidepressant effects of different concentrations of ifenprodil in social frustration stress models

作　　者：赵雨桐 于骁 杨新宇 赵欣怡 周恩泽 田铮[1] Zhao Yu-tong;Yu Xiao;Yang Xin-yu;Zhao Xin-yi;Zhou En-ze;Tian Zheng(Chengde Medical College,Chengde 067000,China)

机构地区：[1]承德医学院,河北承德067000

出　　处：《医学食疗与健康》2022年第3期11-14,共4页Medical Diet and Health

摘　　要：目的:观察不同浓度艾芬地尔对社会压力应激后小鼠抑郁样行为的影响,研究其作为快速持久抗抑郁药的最适浓度。方法:将C57BL/6小鼠成功建立社会压力应激模型后,分别给予0.3 mg/kg、1 mg/kg和3 mg/kg艾芬地尔腹腔注射,通过运动、悬尾、强迫游泳和1%蔗糖偏好试验研究,观察其最适浓度。结果:在悬尾、强迫游泳及1%蔗糖偏好试验中,浓度为0.3 mg/kg和1 mg/kg的艾芬地尔在单剂量给药后对小鼠不动时间及蔗糖偏好并没有明显作用,而浓度为3 mg/kg的艾芬地尔在一定程度上降低了小鼠的不动时间并且增加了蔗糖偏好程度。结论:剂量浓度为3 mg/kg的艾芬地尔在社会压力应激模型中有快速持久的抗抑郁作用。Objective:To observe the effect of different concentrations of Efffendil on depression-like behavior in mice after social stress and to study its optimal concentration as a fast-lasting antidepressant.Methods:After successful establishment of social stress model in C57 BL/6 mice,0.3 mg/kg、1 mg/kg and 3 mg/kg ifenprodil,respectively,and the optimal concentration was observed by exercise,suspension tail,forced swimming and 1% sucrose preference test studies.Results:In the overtail,forced swimming and 1% sucrose preference test,ifenprodil of 0.3 mg/kg and 1 mg/kg had no obvious effect on hyperactivity time and sucrose preference after a single dose,while a concentration of 3 mg/kg reduced immobility time and increased sucrose preference.Conclusion:Ifenprodil with a dose concentration of 3 mg/kg has rapid and lasting antidepressant effects in social stress model.

关 键 词：抗抑郁药 选择性NR2B受体拮抗剂 艾芬地尔 社会压力应激模型 

分 类 号：R749.41[医药卫生—神经病学与精神病学]