氟尿嘧啶植入剂在原发性肝癌治疗中的研究进展  

Research progress on fluorouracil implants in treatment of primary liver cancer

作　　者：唐忠浩 黄建钊[1,2] 刘延[2] 沈素雅 Tang Zhonghao;Huang Jianzhao;Liu Yan;Shen Suya(Guizhou Medical University,Guiyang 550000,China;Department of Hepatobiliary Surgery,Guizhou Provincial People’s Hospital,Guiyang 550000,China)

机构地区：[1]贵州医科大学,贵阳550000 [2]贵州省人民医院肝胆外科,贵阳550000

出　　处：《中国肝脏病杂志（电子版）》2022年第1期14-18,共5页Chinese Journal of Liver Diseases：Electronic Version

基　　金：2021年贵州省卫生健康委员会科学技术基金项目(gzwkj2021-169);贵州省人民医院国家自然科学基金培育基金(黔科合平台人才〔2018〕5764-15)。

摘　　要：原发性肝癌是全世界最常见的肿瘤之一,在我国居常见恶性肿瘤第4位和肿瘤致死病因第2位。肝癌术后复发率和转移率均较高,而其原因可能是术中残留的微量癌细胞在机体处于免疫功能抑制状态下进入增殖期。氟尿嘧啶作为细胞周期特异性药物,其在体内转化形成的活性代谢产物与胸腺嘧啶合成酶形成稳定复合物,使DNA和RNA无法正常进行复制,是其发挥抗肿瘤作用的主要机制。氟尿嘧啶植入剂作为一种缓释剂药物,能以高浓度形式在植入局部区域持续起到抗肿瘤作用,且全身不良反应较小,对胃癌、结直肠癌、乳腺癌和肝癌均有一定疗效。在肝癌切除术中植入氟尿嘧啶植入剂可有效降低术后甲胎蛋白等肿瘤指标物水平及术后复发率,提高患者术后缓解率和生存时间,无明显并发症和不良反应。氟尿嘧啶植入剂可观的临床效果为目前肝癌的治疗带来了新的思路,本文就氟尿嘧啶植入剂在肝癌治疗中的研究现状和进展进行综述。Primary liver cancer is one of the most common tumors in the world,and it is also the fourth most common malignant tumor and the second cause of tumor death in China.Both the postoperative recurrence and metastasis rates of primary liver cancer are high,the reason may be the minimal residual cancer cells after surgery,which can enter proliferation period at the moment when human body is in an immunosuppressive state.As a cell cycle-specific drug,fluorouracil can form stable complexes with thymine synthetase in body,which causes the failure of DNA and RNA’s replication.Fluorouracil implants,as a slow-release drug,play an anti-tumor role in the form of high concentrations in the implanted local areas,without the toxic side effects of systemic chemotherapy and have a certain curative effect on gastric cancer,colorectal cancer,breast cancer and liver cancer.The implantation of fluorouracil implants in liver cancer resection can effectively reduce the level of tumor indicators such as postoperative alpha fetoprotein,and can also reduce the recurrence rate after surgery,increasing the postoperative remission rate and survival time,and have no obvious complications and adverse reactions.The considerable clinical effect of fluorouracil implants has brought new ideas to the treatment of liver cancer.The research progress on fluorouracil implants in the treatment of primary liver cancer were reviewed in this paper.

关 键 词：原发性肝癌 氟尿嘧啶植入剂 治疗效果 

分 类 号：R735.7[医药卫生—肿瘤]