胃肠道恶性肿瘤转化治疗的现状与展望  

Current situation and prospect of transformation therapy for gastrointestinal malignant tumors

作　　者：叶再元[1] 钱振渊[1] Ye Zaiyuan;Qian Zhenyuan(General Surgery,Department of Gastrointestinal and Pancreatic Surgery,Zhejiang Provincial People′s Hospital(Affiliated People′s Hospital,Hangzhou Medical College),Hangzhou 310014,China)

机构地区：[1]浙江省人民医院(杭州医学院附属人民医院)普通外科胃肠胰外科,杭州310014

出　　处：《中国医师杂志》2022年第3期321-325,共5页Journal of Chinese Physician

基　　金：浙江省自然科学基金(LY21H160053)。

摘　　要：胃肠道恶性肿瘤的发病率和死亡率在全球范围内居高不下,严重影响人类的生命健康。随着转化治疗概念的不断普及和深入,许多的临床实践,特别是一些多中心临床研究,证明部分晚期肿瘤的治疗依然存在机会,可以获得良好的生存获益。并且,近些年来,肿瘤认识、外科技术、诊断、化疗及生物免疫治疗等领域发生了一系列变化,导致肿瘤治疗的选择也发生了改变。本文就近几年来晚期胃肠道恶性肿瘤在肝转移、淋巴转移及腹膜转移方面的转化治疗进行简要综述,以期通过总结国内外的相关研究结果,使转化治疗在实践过程中更加科学和规范。The incidence rate and mortality rate of gastrointestinal malignant tumor are high all over the world,which seriously affects human life and health.With the continuous popularization and deepening of the concept of transformation therapy,many clinical practices,especially some multicenter clinical studies,have proved that there are still opportunities for the treatment of some advanced tumors and can obtain good survival benefits.Moreover,in recent years,a series of changes have taken place in the fields of tumor cognition,surgical technology,diagnosis,chemotherapy and biological immunotherapy,resulting in changes in the choice of tumor treatment.This paper briefly reviews the transformation treatment of advanced gastrointestinal malignant tumors in liver metastasis,lymphatic metastasis and peritoneal metastasis in recent years,in order to make the transformation treatment more scientific and standardized in practice by summarizing the relevant research results at home and abroad.

关 键 词：胃肠肿瘤 转化治疗 手术 化学疗法 免疫疗法 

分 类 号：R735[医药卫生—肿瘤]