VEGF、SCCAg、miRNA let-7a对喉癌转移及复发的预测价值  

The predictive value of VEGF,SCCAg and miRNA let-7a in the metastasis and recurrence of laryngeal carcinoma

作　　者：王永宝[1] 肖跃华[1] 刘伟[1] 张美伦 张旭宇[2] 李冬雷[2] Wang Yongbao;Xiao Yuehua;Liu Wei;Zhang Meilun;Zhang Xuyu;Li Donglei(Department of Otorhinolaryngology,the Second Central Hospital of Baoding,Zhuozhou 072750,China;Department of Oncology,the Second Central Hospital of Baoding,Zhuozhou 072750,China)

机构地区：[1]保定市第二中心医院耳鼻喉科,涿州072750 [2]保定市第二中心医院肿瘤科,涿州072750

出　　处：《中国医师杂志》2022年第3期401-405,410,共6页Journal of Chinese Physician

摘　　要：目的探讨血清血管内皮生长因子(VEGF)、鳞状细胞癌相关抗原(SCCAg)、miRNA let-7a对喉癌患者淋巴结转移及术后复发的预测价值。方法回顾性选取2015年11月至2019年10月保定市第二中心医院收治的82例喉癌患者作为研究对象,其中淋巴结转移18例(转移组),未发生淋巴结转移64例(未转移组)。术前检测血常规,比较两组基线资料及血清VEGF、SCCAg、miRNA let-7a水平,采用logistic回归分析喉癌患者淋巴结转移的相关影响因素,分析血清VEGF、SCCAg、miRNA let-7a水平与临床病理特征的相关性,采用受试者工作特征(ROC)曲线分析各指标单独及联合诊断喉癌患者淋巴结转移的价值;随访1年,比较喉癌有、无复发患者血清VEGF、SCCAg、miRNA let-7a水平,采用ROC曲线评价VEGF、SCCAg、miRNA let-7a预测喉癌复发的价值。结果转移组和未转移组喉癌患者TNM分期、浸润深度、分化程度及血清VEGF、SCCAg、miRNA let-7a水平比较,差异有统计学意义(均P<0.05);喉癌患者血清VEGF、SCCAg、miRNA let-7a水平与TNM分期、浸润深度、分化程度有关(均P<0.05);血清VEGF、SCCAg、miRNA let-7a水平联合诊断喉癌患者淋巴结转移的灵敏度、特异度分别为88.89%、70.31%;术后复发患者血清VEGF、SCCAg水平高于未复发患者,miRNA let-7a水平低于未复发患者(均P<0.05);血清VEGF、SCCAg、miRNA let-7a水平联合预测喉癌患者术后复发的灵敏度、特异度分别为72.97%、91.11%。结论喉癌患者血清VEGF、SCCAg、miRNA let-7a水平与临床病理特征存在一定相关性,可辅助诊断喉癌患者淋巴结转移,有助于临床预测喉癌患者术后复发,可为临床治疗方案制定提供参考依据。Objective To investigate the predictive value of serum vascular endothelial growth factor(VEGF),squamous cell carcinoma-associated antigen(SCCAg)and miRNA let-7a in lymph node metastasis and postoperative recurrence in patients with laryngeal cancer.Methods A total of 82 patients with laryngeal cancer in the Second Central Hospital of Baoding from November 2017 to October 2019 were selected as the research subjects,including 18 cases of lymph node metastasis(metastasis group)and 64 cases of non metastasis(non metastasis group).The blood routine was tested before operation,and the baseline data,serum VEGF,SCCAg and miRNA let-7a levels were compared between the two groups.Logistic regression was used to analyze the related influencing factors of lymph node metastasis in patients with laryngeal cancer.The correlation between serum VEGF,SCCAg,miRNA let-7a levels and clinicopathological characteristics was analyzed.The receiver operating characteristic(ROC)curve was used to analyze the value of each index and the combined diagnosis of lymph node metastasis in patients with laryngeal cancer.After 1 year of follow-up,the serum VEGF,SCCAg and miRNA let-7a levels of patients with or without recurrent laryngeal cancer were compared.ROC curve was used to evaluate the value of VEGF,SCCAg,and miRNA let-7a in predicting the recurrence of laryngeal cancer.Results There were statistically significant differences in tumor node metastasis(TNM)stage,degree of infiltration,degree of differentiation,serum VEGF,SCCAg,and miRNA let-7a levels between the metastasis group and non metastasis group(all P<0.05).Serum VEGF,SCCAg,miRNA let-7a levels in patients with laryngeal cancer were related to TNM stage,degree of infiltration and degree of differentiation(all P<0.05).The combined diagnosis of serum VEGF,SCCAg and miRNA let-7a levels in the diagnosis of lymph node metastasis in patients with laryngeal cancer showed that the diagnostic sensitivity and specificity were 88.89%and 70.31%,respectively.The serum VEGF and SCCAg levels of patient

关 键 词：喉肿瘤 血管内皮生长因子 鳞状细胞癌相关抗原 MIRNA let-7a 淋巴转移 肿瘤复发 

分 类 号：R739.65[医药卫生—肿瘤]