Gal3在中枢神经系统退行性疾病中的作用研究进展  

Recent advance in role of galectin-3 in central neurodegenerative diseases

作　　者：范仲煜 侯训尧 刘雪平 殷青青 Fan Zhongyu;Hou Xunyao;Liu Xueping;Yin Qingqing(Department of Geriatric Neurology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院老年神经内科,济南250021

出　　处：《中华神经医学杂志》2022年第2期183-188,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(82000771);山东省自然科学基金(ZR2019PH017);济南市科技计划项目(201805073);中国博士后科学基金(2017M622217)。

摘　　要：半乳糖凝集素-3(Gal3)是一种参与细胞活化、增殖和迁移的多效性蛋白,在多种生理病理过程中发挥重要功能。研究表明,Gal3在中枢神经系统退行性疾病的发病过程中也扮演着重要角色,但其具体作用机制目前尚未完全明确。本文围绕Gal3在中枢神经系统退行性疾病中作用机制及表达水平的研究进展进行综述,探讨Gal3作为中枢神经系统退行性疾病新治疗靶点的应用价值,以期为中枢神经系统退行性疾病的早期防治提供新的科学依据。Galectin-3(Gal3)is a multipotent protein involved in cell activation,proliferation and migration,which plays an important role in a variety of physiological and pathological processes.Recent studies have shown that Gal3 plays an important role in the pathogenesis of central nervous system degenerative diseases,but its specific mechanism is not clear.This article reviews the research progress on the mechanism and expression of Gal3 in central nervous system degenerative diseases,and discusses the application value of Gal3 as a new therapeutic target in central nervous system degenerative diseases,so as to provide new scientific basis for early prevention and treatment of central nervous system degenerative diseases.

关 键 词：半乳糖凝集素-3 中枢神经系统退行性疾病 阿尔茨海默病 帕金森病 亨廷顿病 

分 类 号：R741.02[医药卫生—神经病学与精神病学]