Goal-directed fluid therapy in gastrointestinal cancer surgery:A prospective randomized study  

作　　者：Duygu Akyol Zafer Cukurova Evrim Kucur Tulubas GüneşÖzlem Yıldız Mehmet Süleyman Sabaz 

机构地区：[1]Department of Anesthesiology and Reanimation,BaşakşehirÇam and Sakura City Hospital,Istanbul,Turkey [2]Department of Anesthesiology and Reanimation,Bakirkoy Dr.Sadi Konuk Training and Research Hospital,University of Health Sciences,Istanbul,Turkey [3]Department of Critical Care Medicine,Marmara University Pendik Training and Research Hospital,Marmara University School of Medicine,Istanbul,Turkey

出　　处：《Journal of Acute Disease》2022年第2期52-58,I0001,共8页急性病杂志（英文版）

摘　　要：Objective:To investigate the effects of perioperative goal-directed fluid therapy(GDFT)on intraoperative fluid balance,postoperative morbidity,and mortality.Methods:This is a prospective randomized study,and 90 patients who underwent elective open gastrointestinal cancer surgery between April 2017 and May 2018 were included.Patients were randomized into 2 groups that received liberal fluid therapy(the LFT group,n=45)and goal-directed fluid therapy(the GDFT group,n=45).Patients’Colorectal Physiologic and Operative Severity Score for the enUmeration of Mortality and Morbidity(CR-POSSUM)physiological score,Charlson Comorbidity Index(CCI),perioperative vasopressor and inotrope use,postoperative AKIN classification,postoperative intensive care unit(ICU)hospitalization,hospital stay,and 30-day mortality were recorded.Results:The volume of crystalloid used perioperatively and the total volume of fluid were significantly lower in the GDFT group compared to the LFT group(P<0.05).CR-POSSUM physiological score and CCI were significantly higher in the GDFT group(P<0.05).Although perioperative vasopressor and inotrope use was significantly higher in the GDFT group(P<0.05),postoperative acute kidney injury development was not affected.Postoperative mortality was determined to be similar in both groups(P>0.05).Conclusion:Although GDFT was demonstrated to be a good alternative method to LFT in open gastrointestinal cancer surgery,and it can prevent perioperative fluid overload,and the postoperative results are comparable in the two groups.

关 键 词：Goal-directed fluid therapy Liberal fluid therapy Stroke volume variation Open gastrointestinal cancer surgery 

分 类 号：R73[医药卫生—肿瘤]