B细胞与肿瘤免疫逃逸  

B cells and tumor immune escape

作　　者：李慧婷 李桂源[1] 徐平[2] 李征[1] LI Huiting;LI Guiyuan;XU Ping;LI Zheng(Cancer Research Institute,Central South University,Changsha 410078;Departments of Respiratory and Critical Care Medicine,Peking University Shenzhen Hospital,Shenzhen Guangdong 518036,China)

机构地区：[1]中南大学肿瘤研究所,长沙410078 [2]北京大学深圳医院呼吸内科和危重病内科,广东深圳518036

出　　处：《中南大学学报（医学版）》2022年第3期358-363,共6页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81972773);湖南省自然科学基金(2019JJ40395);深圳市科创委项目(JCYJ20190809103203711);学科创新引智基地项目(111项目,111-2-12)。

摘　　要：B淋巴细胞是人免疫系统中的重要组成细胞,在机体发挥特异性免疫的过程中占有一席之地。近年来关于B细胞与肿瘤免疫逃逸的研究进展迅速。研究表明不同类型的B细胞在肿瘤微环境中通过多样化的机制发挥差异性作用。三级淋巴结构中的B细胞促进肿瘤的免疫杀伤作用,而调节性B细胞促进肿瘤的免疫逃逸。靶向B细胞的抗体药物是肿瘤免疫治疗潜在的新方向。B lymphocyte is an important component of the human immune system and it has a role in the process of the body’ s specific immunity. In recent years, the research on B cells and tumor immune escape has rapidly progressed. Studies have shown that different types of B cells play different roles in tumor microenvironment through a variety of mechanisms. B cells in the tertiary lymphatic structure promote anti-tumor immunity, while regulatory B cells promote tumor immune escape. Antibody drugs targeting B cells are a promising direction for tumor immunotherapy.

关 键 词：B细胞 肿瘤免疫逃逸 三级淋巴结构 调节性B细胞 

分 类 号：R730.3[医药卫生—肿瘤]