二甲双胍对肝细胞癌的诊断、预防及治疗作用  

Role of metformin in the diagnosis, prevention, and treatment of hepatocellular carcinoma

作　　者：熊世泽 刘伟[1] XIONG Shize;LIU Wei(First College of Clinical Medical Science,China Three Gorges University,Institute of Digestive Disease,China Three Gorges University,Department of Gastroenterology,Yichang Central People’s Hospital,Yichang Hubei 443000,China)

机构地区：[1]三峡大学第一临床医学院,三峡大学消化疾病研究所,宜昌市中心人民医院消化内科,湖北宜昌443000

出　　处：《中南大学学报（医学版）》2022年第3期364-373,共10页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(31600134)。

摘　　要：肝细胞癌是全球最常见的恶性肿瘤之一,虽然对肝细胞癌的治疗有手术切除、介入治疗、放射治疗、化学治疗、靶向治疗以及肝移植等多种方案,但总体效果并不理想。这严重影响患者的生活质量,也加重了社会和经济负担。二甲双胍原为2型糖尿病的一线用药,但人们发现其在恶性肿瘤防治中也具有一定的作用。二甲双胍在肝细胞癌防治中具有潜在作用,如调控肝细胞癌微环境、增殖信号通路、代谢、侵袭和转移、凋亡、自噬和表观遗传学等,为肝细胞癌的防治提供了新选择。Hepatocellular carcinoma is one of the most common malignant tumors in the world.Although there are many options for the treatment of hepatocellular carcinoma, such as surgical resection, interventional therapy, radiotherapy, chemotherapy, targeted therapy and liver transplantation, the poor therapeutic effect seriously reduces the quality of life for patients and also increases the social and economic burden. Metformin is originally used as the first-line drug for type 2 diabetes, but it has been found to play a certain effect in the prevention and treatment of malignant tumor. The potential roles of metformin against hepatocellular carcinoma, such as regulation of the microenvironment, proliferation signal pathway, metabolism, invasion and metastasis, apoptosis, autophagy, and epigenetics of hepatoma cells. It provides a new choice for the prevention and treatment of hepatocellular carcinoma.

关 键 词：肝细胞癌 二甲双胍 作用机制 

分 类 号：R735.7[医药卫生—肿瘤]