C-KIT基因突变对儿童核心结合因子相关急性髓系白血病预后影响的Meta分析  

Effect of C-KIT gene mutation on the prognosis of acute myeloid leukemia associated with core-binding factor in children:a Meta-analysis

作　　者：陈千 翟一蔓 刘文君 Chen Qian;Zhai Yiman;Liu Wenjun(Department of Pediatrics(Hematologic Neoplasms Ward),the Affiliated Hospital of Southwest Medical University,Sichuan Clinical Research Center for Birth Defects,Luzhou 646000,China)

机构地区：[1]西南医科大学附属医院儿科(血液肿瘤病区)四川省出生缺陷临床医学研究中心,泸州646000

出　　处：《白血病．淋巴瘤》2022年第2期111-116,共6页Journal of Leukemia & Lymphoma

基　　金：四川省应用基础研究项目([2019Y]0690);四川省科技厅重点研发项目(2019YFS0531)。

摘　　要：目的系统评价C-KIT基因突变与儿童核心结合因子相关急性髓系白血病(CBF-AML)预后的关系。方法以"KIT""Acute Myeloid Leukemia""Children"为英文检索词检索PubMed数据库;以"KIT""急性髓系白血病""儿童"为检索词检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普数据库、万方数据库,检索时间为建库至2020年10月1日。文献经过严格筛选后纳入分析;根据基因检测明确有无基因改变,分为C-KIT突变组和野生组,分析两组完全缓解(CR)率、无事件生存(EFS)率、总生存(OS)率的差异。结果共纳入6篇文献,其中英文文献4篇,中文文献2篇,共667例患者。儿童CBF-AML患者中,C-KIT突变组与野生组EFS率比较,差异有统计学意义(HR=2.40,95%CI 1.47~3.89,P=0.001);两组CR率和OS率差异均无统计学意义(OR=0.93,95%CI 0.48~1.80,P=0.830;HR=1.92,95%CI 0.96~3.83,P=0.065)。结论C-KIT基因突变可能是儿童CBF-AML患者预后不良的危险因素。Objective To systematically evaluate the relationship between C-KIT gene mutation and the prognosis of childhood core-binding factor-related acute myeloid leukemia(CBF-AML).Methods The PubMed database was searched with"KIT""Acute Myeloid Leukemia"and"Children";the Chinese Journal Full-text Database(CNKI),Chinese Biomedical Literature Database(CBM),VIP database and Wanfang database were also searched with"KIT""Acute Myeloid Leukemia"and"Children",and the search time was from the establishment of the database to October 1,2020.After strict screening,the literature was included in the analysis;according to the presence or absence of genetic changes,the included cases was divided into C-KIT mutation group and wild group,and the complete remission(CR)rate,event-free survival(EFS)rate,and overall survival(OS)rate of the two groups were analyzed.Results Six articles were collected,including 4 articles in English and 2 articles in Chinese,with a total of 667 patients.There was a statistically significant difference in the EFS rate between the C-KIT mutation group and wild group in children with CBF-AML(HR=2.40,95%CI 1.47-3.89,P=0.001);there was no significant difference in the CR rate and OS rate(OR=0.93,95%CI 0.48-1.80,P=0.830;HR=1.92,95%CI 0.96-3.83,P=0.065)between the two groups.Conclusions C-KIT gene mutation may be a risk factor for poor prognosis in children with CBF-AML.

关 键 词：白血病 髓样 急性 儿童 核心结合因子类 原癌基因蛋白质C-KIT 

分 类 号：R733.71[医药卫生—肿瘤]