儿童中枢神经系统白血病研究进展  

Research progress of the central nervous system leukemia in children

作　　者：魏昂 郑胡镛[1] 王彬[1] Wei Ang;Zheng Huyong;Wang Bin(National Center for Children′s Health Hematology Center,Beijing Children′s Hospital,Capital Medical University Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Disease in Children Ministry of Education,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院血液病中心,儿童血液病与肿瘤分子分型北京市重点实验室,儿科学国家重点学科,儿科重大疾病研究教育部重点实验室,北京100045

出　　处：《中华实用儿科临床杂志》2022年第2期146-149,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家科技重大专项(2017ZX09304029001)。

摘　　要：急性白血病是儿童时期最常见的肿瘤,随着危险度分层治疗的不断完善,其完全缓解率有了明显提高。然而中枢神经系统白血病(CNSL)仍是白血病死亡和复发的主要原因之一。现就儿童CNSL的发病机制、诊断及治疗的研究进展进行综述,进一步提高临床医师对该病的认识。Acute leukemia(AL)is the most common tumor in childhood.With the improvement of risk stratification therapy,the complete remission rate of AL has been significantly improved.However,central nervous system leukemia(CNSL)remains the major cause of recurrence and death of leukemia.This study aims to review the pathogenesis,diagnosis and treatment of CNSL in children,hoping to further improve the understanding.

关 键 词：儿童 中枢神经系统白血病 发病机制 诊断 治疗 

分 类 号：R733.7[医药卫生—肿瘤]