调强放疗联合同期CF方案对食管鳞癌IGF-1、VEGF的影响及预后分析  

Effect of intensity modulated radiotherapy combined with CF regimen on IGF-1 and VEGF in esophageal squamous cell carcinoma and its prognostic analysis

作　　者：唐磊 刘涛[1] 贾勋超 赵长林[2] TANG Lei;LIU Tao;JIA Xunchao;ZHAO Changlin(Department of Oncology,Ya'an People's Hospital&Ya'an Hospital,West China Hospital of Sichuan University,Ya'an,Sichuan 625000,China;Department of Gastrointestinal Oncology,Xinhua Hospital Affiliated of Dalian University,Dalian,Liaoning 116000,China)

机构地区：[1]雅安市人民医院四川大学华西医院雅安医院肿瘤科,四川省雅安市625000 [2]大连大学附属新华医院胃肠肿瘤内科,辽宁省大连市116000

出　　处：《中南医学科学杂志》2022年第2期245-248,共4页Medical Science Journal of Central South China

摘　　要：目的探讨调强放疗联合CF方案(顺铂和5-氟尿嘧啶)对食管鳞癌胰岛素样生长因子-1(IGF-1)、血管内皮生长因子(VEGF)的影响及预后分析。方法选择90例食管鳞癌患者,随机均分为联合组(CF方案+调强放疗)和CF组(CF方案),另选择同期30例健康志愿者为对照组。比较各组临床疗效、生活质量、血清IGF-1和VEGF水平及生存期,应用单因素和多因素Cox回归分析确定预后的独立影响因素。结果治疗后,联合组临床有效率和总生存率高于CF组(P<0.05);两组生活质量评分和血清IGF-1和VEGF下降,且联合组低于CF组(P<0.05)。3年总生存率与性别、病灶长度、淋巴结转移、分化程度、浸润深度及TNM分期等相关(P<0.05)。Cox回归显示,淋巴结转移、病灶长度、分化程度和联合治疗是预后的独立影响因素(P<0.05)。结论调强放疗联合CF方案可明显改善患者生活质量,提高临床疗效,且安全性高。淋巴结转移、病灶长度、分化程度及联合治疗是其预后的影响因素。Aim To investigate the effect and prognosis of intensity modulated radiotherapy combined with CF regimen(cisplatin and 5-fluorouracil)on insulin-like growth factor-1(IGF-1)and vascular endothelial growth factor(VEGF)in esophageal squamous cell carcinoma.Methods 90 patients with esophageal squamous cell carcinoma were randomly divided into united group(CF regimen+intensity modulated radiotherapy)and CF group(CF regimen).At the same time,30 healthy volunteers in the same period were selected as the control group.The clinical efficacy,quality of life,serum IGF-1 and VEGF levels and survival time were compared.Univariate and multivariate Cox regression analysis was used to determine the independent factors affecting the prognosis.Results After treatment,the clinical effective rate and 3-year overall survival rate in the united group were higher than that in the CF group(P<0.05);The scores of serum IGF-1 and VEGF in the united group were lower than those in the CF group(P<0.05).The 3-year overall survival rate was related to gender,lesion length,lymph node metastasis,degree of differentiation,depth of invasion and TNM stage(P<0.05).Cox regression analysis showed that lymph node metastasis,lesion length,degree of differentiation and combined treatment were independent factors affecting the prognosis of patients(P<0.05).Conclusions Intensity modulated radiotherapy combined with CF regimen can significantly improve the quality of life,the clinical efficacy and have high safety.Lymph node metastasis,lesion length,degree of differentiation and combined treatment are the main factors affecting the prognosis of patients.

关 键 词：调强放疗 顺铂 5-氟尿嘧啶 食管鳞癌 IGF-1 VEGF 预后 影响因素 

分 类 号：R735.1[医药卫生—肿瘤]