替硝唑合剂联合甲醛甲酚封药治疗牙体牙髓病患者的效果  

Effects of Tinidazole mixture combined with Formaldehyde cresol sealing in treatment of patients with dental pulp disease

作　　者：孙诗雨 SUN Shiyu(Dalian Municipal Central Hospital,Dalian 116031 Liaoning,China)

机构地区：[1]大连市中心医院,辽宁大连116031

出　　处：《中国民康医学》2022年第5期52-54,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察替硝唑合剂联合甲醛甲酚封药治疗牙体牙髓病患者的效果。方法:选取80例牙体牙髓病患者为研究对象,采用随机数字表法分为对照组与观察组各40例。对照组采用甲醛甲酚封药治疗,观察组在对照组基础上联合替硝唑合剂封药治疗。比较两组疗效、不良反应发生率、复发率和治疗前后龈沟液炎性指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平。结果:观察组治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);观察组不良反应发生率为5.00%,低于对照组的22.50%,差异有统计学意义(P<0.05);观察组复发率为2.50%,低于对照组的20.00%,差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:替硝唑合剂联合甲醛甲酚封药治疗牙体牙髓病患者可提高治疗总有效率,降低不良反应发生率、复发率和龈沟液炎性指标水平,优于单纯甲醛甲酚封药治疗效果。Objective:To observe effects of Tinidazole mixture combined with Formaldehyde cresol sealing in treatment of patients with dental pulp disease.Methods:80 patients with dental pulp disease were selected as the research objects and were divided into control group and observation group by using the random number table method,40 cases in each group.The control group was treated with Formaldehyde cresol sealing,while the observation group was combined with Tinidazole mixture sealing treatment on the basis of that of the control group.The curative effects,the incidence of adverse reactions,the recurrence rate,and the levels of inflammatory indexes[interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]in the gingival crevicular fluid before and after the treatment were compared between the two groups.Results:The total effective rate in the observation group was 95.00%,which was higher than 80.00% in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%,which was lower than 22.50% in the control group,and the difference was statistically significant(P<0.05).The recurrence rate in the observation group was 2.50%,which was lower than 20.00% in the control group,and the difference was statistically significant(P<0.05).Further,after the treatment,the levels of IL-6 and TNF-α in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).Conclusions:Tinidazole mixture combined with Formaldehyde cresol sealing in the treatment of the dental pulp disease patients can improve the total effective rate of treatment,and reduce the incidence of adverse reactions,the recurrence rate and the gingival crevicular fluid inflammatory index levels.Moreover,it is superior to single Formaldehyde cresol sealing treatment.

关 键 词：替硝唑合剂 甲醛甲酚 牙体牙髓病 复发率 龈沟液 炎性指标 不良反应 

分 类 号：R781.3[医药卫生—口腔医学]