RNF180在胃癌中的研究进展  

Research progress of RNF180 in gastric cancer

作　　者：张雅婷[1,2] 魏育才 李玉民[1,2] Zhang Yating;Wei Yucai;Li Yumin(Second Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;Gansu Provincial Key Laboratory of Gastrointestinal Tumors,Lanzhou 730030,Gansu,China)

机构地区：[1]兰州大学第二临床医学院,甘肃兰州730000 [2]甘肃省消化系肿瘤重点实验室,甘肃兰州730030

出　　处：《生物医学转化》2022年第1期13-19,45,共8页Biomedical transformation

基　　金：国家自然基金项目(31770537);甘肃省科技重大专项(20ZD7FA003);甘肃省教育厅项目(2021jyjbgs-02);甘肃省青年科技基金项目(20JR5RA321)。

摘　　要：RNF180是具有泛素连接酶活性的一类环指蛋白,可通过参与泛素-蛋白酶体系统影响细胞增殖、分化及凋亡等多种生理过程。研究表明,RNF180在肿瘤中多呈低表达,可抑制胃癌细胞的增殖侵袭,影响胃癌淋巴结转移及预后。RNF180的启动子甲基化引起的基因表达沉默是导致RNF180蛋白在肿瘤中低表达的主要原因,重要甲基化位点与癌前病变、胃癌淋巴结转移及患者预后相关。故RNF180具有成为胃癌肿瘤生物标志物的潜力。RNF180 is a type of ring finger protein with ubiquitin ligase activity,which can affect various physiological processes such as cell proliferation,differentiation and apoptosis by participating in the ubiquitinproteasome system.Studies have shown that RNF180 is mostly low-expressed in tumors,which can inhibit the proliferation and invasion of gastric cancer cells,and affect the lymph node metastasis and prognosis of gastric cancer.The gene expression silencing caused by the methylation of the promoter of RNF180 is the main reason for the low expression of RNF180 protein in tumors.Important methylation sites are related to precancerous lesions,lymph node metastasis of gastric cancer and patient prognosis.Therefore,RNF180 has the potential to become a biomarker of gastric cancer tumors.

关 键 词：RNF180 胃癌 泛素 DNA甲基化 

分 类 号：R735.2[医药卫生—肿瘤]